Floridoside suppresses pro-inflammatory responses by blocking MAPK signaling in activated microglia

Kim, MinJeong, Li, Yong-Xin, Dewapriya, Pradeep, Ryu, BoMi and Kim, Se-Kwon (2013) Floridoside suppresses pro-inflammatory responses by blocking MAPK signaling in activated microglia. BMB Reports, 46 8: 398-403. doi:10.5483/BMBRep.2013.46.8.237


Author Kim, MinJeong
Li, Yong-Xin
Dewapriya, Pradeep
Ryu, BoMi
Kim, Se-Kwon
Title Floridoside suppresses pro-inflammatory responses by blocking MAPK signaling in activated microglia
Journal name BMB Reports   Check publisher's open access policy
ISSN 1976-6696
1976-670X
Publication date 2013-08-01
Sub-type Article (original research)
DOI 10.5483/BMBRep.2013.46.8.237
Open Access Status DOI
Volume 46
Issue 8
Start page 398
End page 403
Total pages 6
Place of publication Kangnam-Seoul, Korea, Republic of
Publisher Korean Society for Biochemistry and Molecular Biology
Language eng
Formatted abstract
Inflammatory conditions mediated by activated microglia lead to chronic neuro-degenerative diseases such as Alzheimer's, Parkinson's, and Huntington's diseases. This study was conducted to determine the effect of floridoside isolated from marine red algae Laurencia undulata on LPS (100 ng/ml) activated inflammatory responses in BV-2 microglia cells. The results show that floridoside has the ability to suppress pro-inflammatory responses in microglia by markedly inhibiting the production of nitric oxide (NO) and reactive oxygen species (ROS). Moreover, floridoside down-regulated the protein and gene expression levels of iNOS and COX-2 by significantly blocking the phosphorylation of p38 and ERK in BV-2 cells. Collectively, these results indicate that floridoside has the potential to be developed as an active agent for the treatment of neuro-inflammation.
Keyword Alzheimer's disease
Floridoside
Laurencia undulata
Neuro inflammation
Oxidative stress
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Pharmacy Publications
 
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