Inward Rectification in Rat Olfactory Receptor Neurons

Lynch, JW and Barry, PH (1991) Inward Rectification in Rat Olfactory Receptor Neurons. Proceedings of the Royal Society B-Biological Sciences, 243 1307: 149-153. doi:10.1098/rspb.1991.0024


Author Lynch, JW
Barry, PH
Title Inward Rectification in Rat Olfactory Receptor Neurons
Journal name Proceedings of the Royal Society B-Biological Sciences   Check publisher's open access policy
ISSN 0962-8452
Publication date 1991-02-01
Year available 1991
Sub-type Article (original research)
DOI 10.1098/rspb.1991.0024
Open Access Status Not yet assessed
Volume 243
Issue 1307
Start page 149
End page 153
Total pages 5
Place of publication LONDON
Publisher ROYAL SOC
Language eng
Abstract Inwardly rectifying currents in enzymically dissociated olfactory receptor neurons of rat were studied by using patch-clamp techniques. Upon hyperpolarization to membrane potentials more negative than -100 mV, small inward-current relaxations were observed. Activation was described by a single exponential with a time constant that decreased e-fold for a 21 mV hyperpolarization. The current was not reduced by the external application of 5 mM Ba2+, but was abolished by the addition of 5 mM Cs+ to the bath solution. Increasing the external K+ concentration ([K+]o) to 25 mM dramatically enhanced the current without affecting the voltage range or the kinetics of activation. In 25 mM [K+]o, tail currents reversed at -26 mV, significantly more positive than the K+ equilibrium potential of -44 mV. These characteristics are consistent with those of a mixed Na+/K+ inward rectification that has been reported in several types of neuronal, cardiac and smooth muscle cells. The current may contribute to controlling cell excitability during the response to some odorants.
Keyword Voltage-Clamp Analysis
Anomalous Rectification
Patch-Clamp
Potassium Current
Tiger Salamander
Cells
Membrane
Starfish
Invitro
Egg
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: ResearcherID Downloads - Archived
 
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