An Analysis of Na+ Currents in Rat Olfactory Receptor Neurons

Rajendra, S, Lynch, JW and Barry, PH (1992) An Analysis of Na+ Currents in Rat Olfactory Receptor Neurons. Pflugers Archiv-European Journal of Physiology, 420 3-4: 342-346. doi:10.1007/BF00374468

Author Rajendra, S
Lynch, JW
Barry, PH
Title An Analysis of Na+ Currents in Rat Olfactory Receptor Neurons
Journal name Pflugers Archiv-European Journal of Physiology   Check publisher's open access policy
ISSN 0031-6768
Publication date 1992-03-01
Year available 1992
Sub-type Article (original research)
DOI 10.1007/BF00374468
Open Access Status Not yet assessed
Volume 420
Issue 3-4
Start page 342
End page 346
Total pages 5
Place of publication NEW YORK
Publisher Springer-Verlag
Language eng
Abstract Na+ currents were observed in acutely-dissociated adult rat olfactory receptor neurons using the wholecell recording techniques. The threshold for current activation was near -70 mV and currents were fully activated by -10 mV (midpoint: -45 mV). Steady-state inactivation was complete at potentials more positive than -70 mV and half complete at -110 mV (+/- < 1, n = 8). Complete recovery from inactivation required one second at -100 mV (n = 7). The addition of 10-mu-M tetrodotoxin or 1 mM Zn2+ to the external solution was required to completely block the current. The current differs from those in amphibian and cultured neonatal rat olfactory neurons in its unusually negative voltage-dependence and slow recovery. Since mammalian olfactory neurons have very high input resistances, physiological resting potentials cannot usually be measured using whole-cell recording techniques. However, predominantly-capacitatively-coupled spikes activated by depolarisation were frequently observed in cell-attached patches. This indicates that the cells were excitable and implies that they must have had resting potentials more negative than -90 mV in order for this current to underlie the action potential.
Keyword Patch-Clamp
Olfactory Receptor Neurons
Sodium Channels
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: ResearcherID Downloads - Archived
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