Slowly Activating K+ Channels in Rat Olfactory Receptor Neurons

Lynch, JW and Barry, PH (1991) Slowly Activating K+ Channels in Rat Olfactory Receptor Neurons. Proceedings of the Royal Society B-Biological Sciences, 244 1311: 219-225. doi:10.1098/rspb.1991.0074


Author Lynch, JW
Barry, PH
Title Slowly Activating K+ Channels in Rat Olfactory Receptor Neurons
Journal name Proceedings of the Royal Society B-Biological Sciences   Check publisher's open access policy
ISSN 0962-8452
Publication date 1991-06-01
Year available 1991
Sub-type Article (original research)
DOI 10.1098/rspb.1991.0074
Open Access Status Not yet assessed
Volume 244
Issue 1311
Start page 219
End page 225
Total pages 7
Place of publication LONDON
Publisher ROYAL SOC
Language eng
Abstract Patch-clamp techniques were used to investigate slowly activating, Ca2+-insensitive K+ channels of isolated rat olfactory receptor neurons. These channels had a unitary conductance of 135 pS and were only found in a small proportion (less than 5%) of membrane patches. Upon depolarization to voltages more positive than -50 mV, the channels activated gradually over a period of at least 10 s. When hyperpolarized to negative voltages, channel activity deactivated in a slow but voltage-dependent manner. These channels may underlie a slowly activating K+ current that is observed in approximately 30% of whole-cell recordings. Similar single channels have been reported in smooth muscle cells, but this is the first demonstration of these channels in any type of neuron. The channels may contribute to the spike frequency adaptation and post-stimulus hyperpolarization that are observed during the excitatory response to odorants. They may also contribute to cell repolarization following large odorant-stimulated receptor currents.
Keyword Spike Frequency Adaptation
Patch-Clamp
Potassium Channels
Cells
Currents
Cloning
Atrium
Rna
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: ResearcherID Downloads - Archived
 
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