The epidemiological modelling of dysthymia: Application for the Global Burden of Disease Study 2010

Charlson, Fiona J., Ferrari, Alize J., Flaxman, Abraham D. and Whiteford, Harvey A. (2013) The epidemiological modelling of dysthymia: Application for the Global Burden of Disease Study 2010. Journal of Affective Disorders, 151 1: 111-120. doi:10.1016/j.jad.2013.05.060

Author Charlson, Fiona J.
Ferrari, Alize J.
Flaxman, Abraham D.
Whiteford, Harvey A.
Title The epidemiological modelling of dysthymia: Application for the Global Burden of Disease Study 2010
Journal name Journal of Affective Disorders   Check publisher's open access policy
ISSN 0165-0327
Publication date 2013-10-01
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.jad.2013.05.060
Volume 151
Issue 1
Start page 111
End page 120
Total pages 10
Place of publication Amsterdam, The Netherlands
Publisher Elsevier BV
Language eng
Formatted abstract
Background: In order to capture the differences in burden between the subtypes of depression, the Global Burden of Disease 2010 Study for the first time estimated the burden of dysthymia and major depressive disorder separately from the previously used umbrella term 'unipolar depression'. A global summary of epidemiological parameters are necessary inputs in burden of disease calculations for 21 world regions, males and females and for the year 1990, 2005 and 2010. This paper reports findings from a systematic review of global epidemiological data and the subsequent development of an internally consistent epidemiological model of dysthymia.

A systematic search was conducted to identify data sources for the prevalence, incidence, remission and excess-mortality of dysthymia using Medline, PsycINFO and EMBASE electronic databases and grey literature. DisMod-MR, a Bayesian meta-regression tool, was used to check the epidemiological parameters for internal consistency and to predict estimates for world regions with no or few data.

Results: The systematic review identified 38 studies meeting inclusion criteria which provided 147 data points for 30 countries in 13 of 21 world regions. Prevalence increases in the early ages, peaking at around 50 years. Females have higher prevalence of dysthymia than males. Global pooled prevalence remained constant across time points at 1.55% (95%CI 1.50-1.60). There was very little regional variation in prevalence estimates. Limitations: There were eight GBD world regions for which we found no data for which DisMod-MR had to impute estimates.

The addition of internally consistent epidemiological estimates by world region, age, sex and year for dysthymia contributed to a more comprehensive estimate of mental health burden in GBD 2010
Keyword Dysthymia
Mental disorders
Global public health
Systematic review
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Public Health Publications
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