Early pregnancy factor: tissues involved in its production in the mouse

Morton, H., Rolfe, B. E., McNeill, L., Clarke, P., Clarke, F. M. and Clunie, G. J. A. (1980) Early pregnancy factor: tissues involved in its production in the mouse. Journal of Reproductive Immunology, 2 2: 73-82. doi:10.1016/0165-0378(80)90044-3

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Author Morton, H.
Rolfe, B. E.
McNeill, L.
Clarke, P.
Clarke, F. M.
Clunie, G. J. A.
Title Early pregnancy factor: tissues involved in its production in the mouse
Journal name Journal of Reproductive Immunology   Check publisher's open access policy
ISSN 0165-0378
Publication date 1980-06-01
Sub-type Article (original research)
DOI 10.1016/0165-0378(80)90044-3
Open Access Status Not Open Access
Volume 2
Issue 2
Start page 73
End page 82
Total pages 10
Place of publication Shannon, Co. Clare, Ireland
Publisher Elsevier Ireland
Language eng
Formatted abstract
The mouse, 24 h after mating, has been used as an experimental model to determine the site of production of early pregnancy factor (EPF). Results have shown that EPF is formed as two separate components, which appear similar to component A and component B formed after dissociation of EPF by 40% ammonium sulphate. Component A is produced by the oviduct during oestrus and pregnancy. It is present in serum during oestrus in an inactive form, that is, not capable of binding with lymphocytes. Component B can be produced in culture from the ovaries of 24-h pregnant mice. Incubation experiments described in this paper show that the production of component B can also be initiated from non-pregnant mouse ovaries, during oestrus or dioestrus, in the presence of both fertilised ovum and non-pregnancy pituitary but not in the presence of fertilised ovum alone. The pituitary from a 24-h pregnant mouse alone can also stimulate the production of component B from oestrous or dioestrous mice.

To summarize, component A is derived from the oviduct and is oestrus-dependent. Component B, the pregnancy-dependent component of EPF, is produced by the ovary; its production can be initiated from non-pregnancy ovaries by the fertilised ovum in cooperation with the pituitary.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Medicine Publications
Australian Institute for Bioengineering and Nanotechnology Publications
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Citation counts: TR Web of Science Citation Count  Cited 44 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 30 times in Scopus Article | Citations
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Created: Wed, 16 Oct 2013, 21:31:38 EST by Cathy Fouhy on behalf of Surgery - Princess Alexandra Hospital