Comparing schizophrenia symptoms in the Iban of Sarawak with other populations to elucidate clinical heterogeneity

McLean, Duncan, Barrett, Robert, Loa, Peter, Thara, Rangaswamy, John, Sujit, McGrath, John, Gratten, Jake and Mowry, Bryan (2013) Comparing schizophrenia symptoms in the Iban of Sarawak with other populations to elucidate clinical heterogeneity. Asia-Pacific Psychiatry, 7 1: 36-44. doi:10.1111/appy.12093

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Author McLean, Duncan
Barrett, Robert
Loa, Peter
Thara, Rangaswamy
John, Sujit
McGrath, John
Gratten, Jake
Mowry, Bryan
Title Comparing schizophrenia symptoms in the Iban of Sarawak with other populations to elucidate clinical heterogeneity
Journal name Asia-Pacific Psychiatry   Check publisher's open access policy
ISSN 1758-5864
Publication date 2013-08-22
Sub-type Article (original research)
DOI 10.1111/appy.12093
Volume 7
Issue 1
Start page 36
End page 44
Total pages 9
Place of publication Richmond, VIC, Australia
Publisher Wiley-Blackwell Publishing Asia
Language eng
Formatted abstract
Introduction The symptom profile of schizophrenia can vary between ethnic groups. We explored selected symptom variables previously reported to be characteristic of schizophrenia in the Iban of Sarawak in transethnic populations from Australia, India, and Sarawak, Malaysia. We tested site differences to confirm previous research, and to explore implications of differences across populations for future investigations.

Methods We recruited schizophrenia samples in Australia (n = 609), India (n = 310) and Sarawak (n = 205) primarily for the purposes of genetic studies. We analyzed seven identified variables and their relationship to site using logistic regression, including: global delusions, bizarre delusions, thought broadcast/insertion/withdrawal delusions, global hallucinations, auditory hallucinations, disorganized behavior, and prodromal duration.

Results We identified a distinct symptom profile in our Sarawak sample. Specifically, the Iban exhibit: low frequency of thought broadcast/insertion/withdrawal delusions, high frequency of auditory hallucinations and disorganized behavior, with a comparatively short prodrome when compared with Australian and Indian populations.

Discussion Understanding between-site variation in symptom profile may complement future transethnic genetic studies, and provide important clues as to the nature of differing schizophrenia expression across ethnically distinct groups. A comprehensive approach to subtyping schizophrenia is warranted, utilizing comprehensively ascertained transethnic samples to inform both schizophrenia genetics and nosology.
Keyword Culture
Population characteristic
Psychotic disorder
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article first published online: 22 AUG 2013

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2014 Collection
School of Medicine Publications
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Created: Fri, 04 Oct 2013, 00:34:22 EST by Debra McMurtrie on behalf of Queensland Brain Institute