Where GWAS and epidemiology meet: opportunities for the simultaneous study of genetic and environmental risk factors in schizophrenia

McGrath, John J., Mortensen, Preben Bo, Visscher, Peter M. and Wray, Naomi R. (2013) Where GWAS and epidemiology meet: opportunities for the simultaneous study of genetic and environmental risk factors in schizophrenia. Schizophrenia Bulletin, 39 5: 955-959. doi:10.1093/schbul/sbt108


Author McGrath, John J.
Mortensen, Preben Bo
Visscher, Peter M.
Wray, Naomi R.
Title Where GWAS and epidemiology meet: opportunities for the simultaneous study of genetic and environmental risk factors in schizophrenia
Journal name Schizophrenia Bulletin   Check publisher's open access policy
ISSN 0586-7614
1745-1701
Publication date 2013-09-01
Sub-type Article (original research)
DOI 10.1093/schbul/sbt108
Open Access Status DOI
Volume 39
Issue 5
Start page 955
End page 959
Total pages 5
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Collection year 2014
Language eng
Formatted abstract
Epidemiologists and geneticists have tended to explore their respective domains independently, and as a consequence, these fields have drifted apart. The aim of this article is to outline how clues from genetics and epidemiology can be combined in order to optimize schizophrenia research. In particular, we will explore how recent developments in statistical genetics might be used to leverage clues from epidemiology. The ultimate goal of this type of research is to help generate better treatments for schizophrenia via the identification of shared pathways and to find modifiable risk factors that could lead to the primary prevention of schizophrenia.
Keyword Genome-wide association study
Epidemiology
Mendelian randomization
Interaction
Polygene score
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2014 Collection
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 24 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 28 times in Scopus Article | Citations
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Created: Thu, 03 Oct 2013, 23:36:32 EST by Debra McMurtrie on behalf of Queensland Brain Institute