Prenatal vitamin D status and risk of psychotic experiences at age 18 years-a longitudinal birth cohort

Sullivan, Sarah, Wills, Andrew, Lawlor, Debbie, McGrath, John and Zammit, Stanley (2013) Prenatal vitamin D status and risk of psychotic experiences at age 18 years-a longitudinal birth cohort. Schizophrenia Research, 148 1-3: 87-92. doi:10.1016/j.schres.2013.05.015


Author Sullivan, Sarah
Wills, Andrew
Lawlor, Debbie
McGrath, John
Zammit, Stanley
Title Prenatal vitamin D status and risk of psychotic experiences at age 18 years-a longitudinal birth cohort
Journal name Schizophrenia Research   Check publisher's open access policy
ISSN 0920-9964
1573-2509
Publication date 2013-08-01
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.schres.2013.05.015
Open Access Status
Volume 148
Issue 1-3
Start page 87
End page 92
Total pages 6
Place of publication Amsterdam Netherlands
Publisher Elsevier BV
Language eng
Subject 2738 Psychiatry and Mental health
2803 Biological Psychiatry
Abstract Background: Low early life vitamin D status is associated with an increased risk of schizophrenia and psychotic experiences. Here we examine if maternal pregnancy vitamin D concentrations are associated with offspring psychotic experiences as young adults.
Formatted abstract
Background
Low early life vitamin D status is associated with an increased risk of schizophrenia and psychotic experiences. Here we examine if maternal pregnancy vitamin D concentrations are associated with offspring psychotic experiences as young adults.
Methods
A community sample of 2047 participants was investigated. Maternal prenatal 25 hydroxyvitamin D (25(OH)D) concentrations were assessed with tandem mass spectroscopy. Psychotic experiences were assessed at age 18 years using a semi-structured clinical interview.
Results
177 cohort members reported suspected or definite psychotic experiences, There was no evidence of an association between maternal 25(OH)D concentrations as quartiles (p = 0.85 hypothesis test of general association versus no association across the quartiles) or as a continuous variable (p = 0.89) versus experience of suspected and definite psychotic experiences at 18 years. Within the cohort, only 29 subjects met criteria for a psychotic disorder at age 18. Based on this sample, there was no significant association between maternal 25(OH)D and psychotic disorder at 18 years.
Discussion
Maternal vitamin D levels were not associated with risk of psychotic experiences nor psychotic disorders in this birth cohort.
Keyword 25-Hydroxyvitamin D
Pre-natal
Psychotic experiences
Birth cohort
Alspac
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 092731
092731
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2014 Collection
School of Medicine Publications
 
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