Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

Lee, S. Hong, Ripke, Stephan, Neale, Benjamin M., Faraone, Stephen V., Purcell, Shaun M., Perlis, Roy H., Mowry, Bryan J., Thapar, Anita, Goddard, Michael E., Witte, John S., Absher, Devin, Agartz, Ingrid, Akil, Huda, Amin, Farooq, Andreassen, Ole A., Anjorin, Adebayo, Anney, Richard, Anttila, Verneri, Arking, Dan E., Asherson, Philip, Azevedo, Maria H., Backlund, Lena, Badner, Judith A., Bailey, Anthony J., Banaschewski, Tobias, Barchas, Jack D., Barnes, Michael R., Barrett, Thomas B., Bass, Nicholas, Battaglia, Agatino, Bauer, Michael, Bayes, Monica, Bellivier, Frank, Bergen, Sarah E., Berrettini, Wade, Betancur, Catalina, Bettecken, Thomas, Biederman, Joseph, Binder, Elisabeth B., Black, Donald W., Blackwood, Douglas H. R., Bloss, Cinnamon S., Boehnke, Michael, Boomsma, Dorret I., Breen, Gerome, Breuer, Rene, Bruggeman, Richard, Cormican, Paul, Buccola, Nancy G., Buitelaar, Jan K., Bunney, William E., Buxbaum, Joseph D., Byerley, William F., Byrne, Enda M., Caesar, Sian, Cahn, Wiepke, Cantor, Rita M., Casas, Miguel, Chakravarti, Aravinda, Chambert, Kimberly, Choudhury, Khalid, Cichon, Sven, Cloninger, C. Robert, Collier, David A., Cook, Edwin H., Coon, Hilary, Cormand, Bru, Corvin, Aiden, Coryell, William H., Craig, David W., Craig, Ian W., Crosbie, Jennifer, Cuccaro, Michael L., Curtis, David, Czamara, Darina, Datta, Susmita, Dawson, Geraldine, Day, Richard, De Geus, Eco J., Degenhardt, Franziska, Djurovic, Srdjan, Donohoe, Gary J., Doyle, Alysa E., Duan, Jubao, Dudbridge, Frank, Duketis, Eftichia, Ebstein, Richard P., Edenberg, Howard J., Elia, Josephine, Ennis, Sean, Etain, Bruno, Fanous, Ayman, Farmer, Anne E., Ferrier, I. Nicol, Flickinger, Matthew, Fombonne, Eric, Foroud, Tatiana, Frank, Josef, Franke, Barbara, Fraser, Christine, Freedman, Robert, Freimer, Nelson B., Freitag, Christine M., Friedl, Marion, Frisen, Louise, Gallagher, Louise, Gejman, Pablo V., Georgieva, Lyudmila, Gershon, Elliot S., Geschwind, Daniel H., Giegling, Ina, Gill, Michael, Gordon, Scott D., Gordon-Smith, Katherine, Green, Elaine K., Greenwood, Tiffany A., Grice, Dorothy E., Gross, Magdalena, Grozeva, Detelina, Guan, Weihua, Gurling, Hugh, De Haan, Lieuwe, Haines, Jonathan L., Hakonarson, Hakon, Hallmayer, Joachim, Hamilton, Steven P., Hamshere, Marian L., Hansen, Thomas F., Hartmann, Annette M., Hautzinger, Martin, Heath, Andrew C., Henders, Anjali K., Herms, Stefan, Hickie, Ian B., Hipolito, Maria, Hoefels, Susanne, Holmans, Peter A., Holsboer, Florian, Hoogendijk, Witte J., Hottenga, Jouke-Jan, Hultman, Christina M., Hus, Vanessa, Ingason, Andres, Ising, Marcus, Jamain, Stephane, Jones, Edward G., Jones, Ian, Jones, Lisa, Tzeng, Jung-Ying, Kaehler, Anna K., Kahn, Rene S., Kandaswamy, Radhika, Keller, Matthew C., Kennedy, James L., Kenny, Elaine, Kent, Lindsey, Kim, Yunjung, Kirov, George K., Klauck, Sabine M., Klei, Lambertus, Knowles, James A., Kohli, Martin A., Koller, Daniel L., Konte, Bettina, Korszun, Ania, Krabbendam, Lydia, Krasucki, Robert, Kuntsi, Jonna, Kwan, Phoenix, Landen, Mikael, Langstrom, Niklas, Lathrop, Mark, Lawrence, Jacob, Lawson, William B., Leboyer, Marion, Ledbetter, David H., Lee, Phil H., Lencz, Todd, Lesch, Klaus-Peter, Levinson, Douglas F., Lewis, Cathryn M., Li, Jun, Lichtenstein, Paul, Lieberman, Jeffrey A., Lin, Dan-Yu, Linszen, Don H., Liu, Chunyu, Lohoff, Falk W., Loo, Sandra K., Lord, Catherine, Lowe, Jennifer K., Lucae, Susanne, MacIntyre, Donald J., Madden, Pamela A. F., Maestrini, Elena, Magnusson, Patrik K. E., Mahon, Pamela B., Maier, Wolfgang, Malhotra, Anil K., Mane, Shrikant M., Martin, Christa L., Martin, Nicholas G., Mattheisen, Manuel, Matthews, Keith, Mattingsdal, Morten, McCarroll, Steven A., McGhee, Kevin A., McGough, James J., McGrath, Patrick J., McGuffin, Peter, McInnis, Melvin G., McIntosh, Andrew, McKinney, Rebecca, McLean, Alan W., McMahon, Francis J., McMahon, William M., McQuillin, Andrew, Medeiros, Helena, Medland, Sarah E., Meier, Sandra, Melle, Ingrid, Meng, Fan, Meyer, Jobst, Middeldorp, Christel M., Middleton, Lefkos, Milanova, Vihra, Miranda, Ana, Monaco, Anthony P., Montgomery, Grant W., Moran, Jennifer L., Moreno-De-Luca, Daniel, Morken, Gunnar, Morris, Derek W., Morrow, Eric M., Moskvina, Valentina, Muglia, Pierandrea, Muehleisen, Thomas W., Muir, Walter J., Mueller-Myhsok, Bertram, Murtha, Michael, Myers, Richard M., Myin-Germeys, Inez, Neale, Michael C., Nelson, Stan F., Nievergelt, Caroline M., Nikolov, Ivan, Nimgaonkar, Vishwajit, Nolen, Willem A., Noethen, Markus M., Nurnberger, John I., Nwulia, Evaristus A., Nyholt, Dale R., O'Dushlaine, Colm, Oades, Robert D., Olincy, Ann, Oliveira, Guiomar, Olsen, Line, Ophoff, Roel A., Osby, Urban, Owen, Michael J., Palotie, Aarno, Parr, Jeremy R., Paterson, Andrew D., Pato, Carlos N., Pato, Michele T., Penninx, Brenda W., Pergadia, Michele L., Pericak-Vance, Margaret A., Pickard, Benjamin S., Pimm, Jonathan, Piven, Joseph, Posthuma, Danielle, Potash, James B., Poustka, Fritz, Propping, Peter, Puri, Vinay, Quested, Digby J., Quinn, Emma M., Antoni Ramos-Quiroga, Josep, Rasmussen, Henrik B., Raychaudhuri, Soumya, Rehnstroem, Karola, Reif, Andreas, Ribases, Marta, Rice, John P., Rietschel, Marcella, Roeder, Kathryn, Roeyers, Herbert, Rossin, Lizzy, Rothenberger, Aribert, Rouleau, Guy, Ruderfer, Douglas, Rujescu, Dan, Sanders, Alan R., Sanders, Stephan J., Santangelo, Susan L., Sergeant, Joseph A., Schachar, Russell, Schalling, Martin, Schatzberg, Alan F., Scheftner, William A., Schellenberg, Gerard D., Scherer, Stephen W., Schork, Nicholas J., Schulze, Thomas G., Schumacher, Johannes, Schwarz, Markus, Scolnick, Edward, Scott, Laura J., Shi, Jianxin, Shilling, Paul D., Shyn, Stanley I., Silverman, Jeremy M., Slager, Susan L., Smalley, Susan L., Smit, Johannes H., Smith, Erin N., Sonuga-Barke, Edmund J. S., St Clair, David, State, Matthew, Steffens, Michael, Steinhausen, Hans-Christoph, Strauss, John S., Strohmaier, Jana, Stroup, T. Scott, Sutcliffe, James S., Szatmari, Peter, Szelinger, Szabocls, Thirumalai, Srinivasa, Thompson, Robert C., Todorov, Alexandre A., Tozzi, Federica, Treutlein, Jens, Uhr, Manfred, van den Oord, Edwin J. C. G., Van Grootheest, Gerard, Van Os, Jim, Vicente, Astrid M., Vieland, Veronica J., Vincent, John B., Visscher, Peter M., Walsh, Christopher A., Wassink, Thomas H., Watson, Stanley J., Weissman, Myrna M., Werge, Thomas, Wienker, Thomas F., Wijsman, Ellen M., Willemsen, Gonneke, Williams, Nigel, Willsey, A. Jeremy, Witt, Stephanie H., Xu, Wei, Young, Allan H., Yu, Timothy W., Zammit, Stanley, Zandi, Peter P., Zhang, Peng, Zitman, Frans G., Zoellner, Sebastian, Devlin, Bernie, Kelsoe, John R., Sklar, Pamela, Daly, Mark J., O'Donovan, Michael C., Craddock, Nicholas, Sullivan, Patrick F., Smoller, Jordan W., Kendler, Kenneth S. and Wray, Naomi R. (2013) Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nature Genetics, 45 9: 984-995. doi:10.1038/ng.2711

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads
UQ310708_OA.pdf Full text (open access) application/pdf 690.68KB 0

Author Lee, S. Hong
Ripke, Stephan
Neale, Benjamin M.
Faraone, Stephen V.
Purcell, Shaun M.
Perlis, Roy H.
Mowry, Bryan J.
Thapar, Anita
Goddard, Michael E.
Witte, John S.
Absher, Devin
Agartz, Ingrid
Akil, Huda
Amin, Farooq
Andreassen, Ole A.
Anjorin, Adebayo
Anney, Richard
Anttila, Verneri
Arking, Dan E.
Asherson, Philip
Azevedo, Maria H.
Backlund, Lena
Badner, Judith A.
Bailey, Anthony J.
Banaschewski, Tobias
Barchas, Jack D.
Barnes, Michael R.
Barrett, Thomas B.
Bass, Nicholas
Battaglia, Agatino
Bauer, Michael
Bayes, Monica
Bellivier, Frank
Bergen, Sarah E.
Berrettini, Wade
Betancur, Catalina
Bettecken, Thomas
Biederman, Joseph
Binder, Elisabeth B.
Black, Donald W.
Blackwood, Douglas H. R.
Bloss, Cinnamon S.
Boehnke, Michael
Boomsma, Dorret I.
Breen, Gerome
Breuer, Rene
Bruggeman, Richard
Cormican, Paul
Buccola, Nancy G.
Buitelaar, Jan K.
Bunney, William E.
Buxbaum, Joseph D.
Byerley, William F.
Byrne, Enda M.
Caesar, Sian
Cahn, Wiepke
Cantor, Rita M.
Casas, Miguel
Chakravarti, Aravinda
Chambert, Kimberly
Choudhury, Khalid
Cichon, Sven
Cloninger, C. Robert
Collier, David A.
Cook, Edwin H.
Coon, Hilary
Cormand, Bru
Corvin, Aiden
Coryell, William H.
Craig, David W.
Craig, Ian W.
Crosbie, Jennifer
Cuccaro, Michael L.
Curtis, David
Czamara, Darina
Datta, Susmita
Dawson, Geraldine
Day, Richard
De Geus, Eco J.
Degenhardt, Franziska
Djurovic, Srdjan
Donohoe, Gary J.
Doyle, Alysa E.
Duan, Jubao
Dudbridge, Frank
Duketis, Eftichia
Ebstein, Richard P.
Edenberg, Howard J.
Elia, Josephine
Ennis, Sean
Etain, Bruno
Fanous, Ayman
Farmer, Anne E.
Ferrier, I. Nicol
Flickinger, Matthew
Fombonne, Eric
Foroud, Tatiana
Frank, Josef
Franke, Barbara
Fraser, Christine
Freedman, Robert
Freimer, Nelson B.
Freitag, Christine M.
Friedl, Marion
Frisen, Louise
Gallagher, Louise
Gejman, Pablo V.
Georgieva, Lyudmila
Gershon, Elliot S.
Geschwind, Daniel H.
Giegling, Ina
Gill, Michael
Gordon, Scott D.
Gordon-Smith, Katherine
Green, Elaine K.
Greenwood, Tiffany A.
Grice, Dorothy E.
Gross, Magdalena
Grozeva, Detelina
Guan, Weihua
Gurling, Hugh
De Haan, Lieuwe
Haines, Jonathan L.
Hakonarson, Hakon
Hallmayer, Joachim
Hamilton, Steven P.
Hamshere, Marian L.
Hansen, Thomas F.
Hartmann, Annette M.
Hautzinger, Martin
Heath, Andrew C.
Henders, Anjali K.
Herms, Stefan
Hickie, Ian B.
Hipolito, Maria
Hoefels, Susanne
Holmans, Peter A.
Holsboer, Florian
Hoogendijk, Witte J.
Hottenga, Jouke-Jan
Hultman, Christina M.
Hus, Vanessa
Ingason, Andres
Ising, Marcus
Jamain, Stephane
Jones, Edward G.
Jones, Ian
Jones, Lisa
Tzeng, Jung-Ying
Kaehler, Anna K.
Kahn, Rene S.
Kandaswamy, Radhika
Keller, Matthew C.
Kennedy, James L.
Kenny, Elaine
Kent, Lindsey
Kim, Yunjung
Kirov, George K.
Klauck, Sabine M.
Klei, Lambertus
Knowles, James A.
Kohli, Martin A.
Koller, Daniel L.
Konte, Bettina
Korszun, Ania
Krabbendam, Lydia
Krasucki, Robert
Kuntsi, Jonna
Kwan, Phoenix
Landen, Mikael
Langstrom, Niklas
Lathrop, Mark
Lawrence, Jacob
Lawson, William B.
Leboyer, Marion
Ledbetter, David H.
Lee, Phil H.
Lencz, Todd
Lesch, Klaus-Peter
Levinson, Douglas F.
Lewis, Cathryn M.
Li, Jun
Lichtenstein, Paul
Lieberman, Jeffrey A.
Lin, Dan-Yu
Linszen, Don H.
Liu, Chunyu
Lohoff, Falk W.
Loo, Sandra K.
Lord, Catherine
Lowe, Jennifer K.
Lucae, Susanne
MacIntyre, Donald J.
Madden, Pamela A. F.
Maestrini, Elena
Magnusson, Patrik K. E.
Mahon, Pamela B.
Maier, Wolfgang
Malhotra, Anil K.
Mane, Shrikant M.
Martin, Christa L.
Martin, Nicholas G.
Mattheisen, Manuel
Matthews, Keith
Mattingsdal, Morten
McCarroll, Steven A.
McGhee, Kevin A.
McGough, James J.
McGrath, Patrick J.
McGuffin, Peter
McInnis, Melvin G.
McIntosh, Andrew
McKinney, Rebecca
McLean, Alan W.
McMahon, Francis J.
McMahon, William M.
McQuillin, Andrew
Medeiros, Helena
Medland, Sarah E.
Meier, Sandra
Melle, Ingrid
Meng, Fan
Meyer, Jobst
Middeldorp, Christel M.
Middleton, Lefkos
Milanova, Vihra
Miranda, Ana
Monaco, Anthony P.
Montgomery, Grant W.
Moran, Jennifer L.
Moreno-De-Luca, Daniel
Morken, Gunnar
Morris, Derek W.
Morrow, Eric M.
Moskvina, Valentina
Muglia, Pierandrea
Muehleisen, Thomas W.
Muir, Walter J.
Mueller-Myhsok, Bertram
Murtha, Michael
Myers, Richard M.
Myin-Germeys, Inez
Neale, Michael C.
Nelson, Stan F.
Nievergelt, Caroline M.
Nikolov, Ivan
Nimgaonkar, Vishwajit
Nolen, Willem A.
Noethen, Markus M.
Nurnberger, John I.
Nwulia, Evaristus A.
Nyholt, Dale R.
O'Dushlaine, Colm
Oades, Robert D.
Olincy, Ann
Oliveira, Guiomar
Olsen, Line
Ophoff, Roel A.
Osby, Urban
Owen, Michael J.
Palotie, Aarno
Parr, Jeremy R.
Paterson, Andrew D.
Pato, Carlos N.
Pato, Michele T.
Penninx, Brenda W.
Pergadia, Michele L.
Pericak-Vance, Margaret A.
Pickard, Benjamin S.
Pimm, Jonathan
Piven, Joseph
Posthuma, Danielle
Potash, James B.
Poustka, Fritz
Propping, Peter
Puri, Vinay
Quested, Digby J.
Quinn, Emma M.
Antoni Ramos-Quiroga, Josep
Rasmussen, Henrik B.
Raychaudhuri, Soumya
Rehnstroem, Karola
Reif, Andreas
Ribases, Marta
Rice, John P.
Rietschel, Marcella
Roeder, Kathryn
Roeyers, Herbert
Rossin, Lizzy
Rothenberger, Aribert
Rouleau, Guy
Ruderfer, Douglas
Rujescu, Dan
Sanders, Alan R.
Sanders, Stephan J.
Santangelo, Susan L.
Sergeant, Joseph A.
Schachar, Russell
Schalling, Martin
Schatzberg, Alan F.
Scheftner, William A.
Schellenberg, Gerard D.
Scherer, Stephen W.
Schork, Nicholas J.
Schulze, Thomas G.
Schumacher, Johannes
Schwarz, Markus
Scolnick, Edward
Scott, Laura J.
Shi, Jianxin
Shilling, Paul D.
Shyn, Stanley I.
Silverman, Jeremy M.
Slager, Susan L.
Smalley, Susan L.
Smit, Johannes H.
Smith, Erin N.
Sonuga-Barke, Edmund J. S.
St Clair, David
State, Matthew
Steffens, Michael
Steinhausen, Hans-Christoph
Strauss, John S.
Strohmaier, Jana
Stroup, T. Scott
Sutcliffe, James S.
Szatmari, Peter
Szelinger, Szabocls
Thirumalai, Srinivasa
Thompson, Robert C.
Todorov, Alexandre A.
Tozzi, Federica
Treutlein, Jens
Uhr, Manfred
van den Oord, Edwin J. C. G.
Van Grootheest, Gerard
Van Os, Jim
Vicente, Astrid M.
Vieland, Veronica J.
Vincent, John B.
Visscher, Peter M.
Walsh, Christopher A.
Wassink, Thomas H.
Watson, Stanley J.
Weissman, Myrna M.
Werge, Thomas
Wienker, Thomas F.
Wijsman, Ellen M.
Willemsen, Gonneke
Williams, Nigel
Willsey, A. Jeremy
Witt, Stephanie H.
Xu, Wei
Young, Allan H.
Yu, Timothy W.
Zammit, Stanley
Zandi, Peter P.
Zhang, Peng
Zitman, Frans G.
Zoellner, Sebastian
Devlin, Bernie
Kelsoe, John R.
Sklar, Pamela
Daly, Mark J.
O'Donovan, Michael C.
Craddock, Nicholas
Sullivan, Patrick F.
Smoller, Jordan W.
Kendler, Kenneth S.
Wray, Naomi R.
Title Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1061-4036
1546-1718
Publication date 2013-09-01
Year available 2013
Sub-type Article (original research)
DOI 10.1038/ng.2711
Open Access Status File (Author Post-print)
Volume 45
Issue 9
Start page 984
End page 995
Total pages 12
Place of publication New York, United States
Publisher Nature Publishing Group
Language eng
Subject 1311 Genetics
Abstract Most psychiatric disorders are moderately to highly heritable. The degree to which genetic variation is unique to individual disorders or shared across disorders is unclear. To examine shared genetic etiology, we use genome-wide genotype data from the Psychiatric Genomics Consortium (PGC) for cases and controls in schizophrenia, bipolar disorder, major depressive disorder, autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD). We apply univariate and bivariate methods for the estimation of genetic variation within and covariation between disorders. SNPs explained 17-29% of the variance in liability. The genetic correlation calculated using common SNPs was high between schizophrenia and bipolar disorder (0.68 ± 0.04 s.e.), moderate between schizophrenia and major depressive disorder (0.43 ± 0.06 s.e.), bipolar disorder and major depressive disorder (0.47 ± 0.06 s.e.), and ADHD and major depressive disorder (0.32 ± 0.07 s.e.), low between schizophrenia and ASD (0.16 ± 0.06 s.e.) and non-significant for other pairs of disorders as well as between psychiatric disorders and the negative control of Crohn's disease. This empirical evidence of shared genetic etiology for psychiatric disorders can inform nosology and encourages the investigation of common pathophysiologies for related disorders.
Formatted abstract
Most psychiatric disorders are moderately to highly heritable. The degree to which genetic variation is unique to individual disorders or shared across disorders is unclear. To examine shared genetic etiology, we use genome-wide genotype data from the Psychiatric Genomics Consortium (PGC) for cases and controls in schizophrenia, bipolar disorder, major depressive disorder, autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD). We apply univariate and bivariate methods for the estimation of genetic variation within and covariation between disorders. SNPs explained 17–29% of the variance in liability. The genetic correlation calculated using common SNPs was high between schizophrenia and bipolar disorder (0.68 ± 0.04 s.e.), moderate between schizophrenia and major depressive disorder (0.43 ± 0.06 s.e.), bipolar disorder and major depressive disorder (0.47 ± 0.06 s.e.), and ADHD and major depressive disorder (0.32 ± 0.07 s.e.), low between schizophrenia and ASD (0.16 ± 0.06 s.e.) and non-significant for other pairs of disorders as well as between psychiatric disorders and the negative control of Crohn's disease. This empirical evidence of shared genetic etiology for psychiatric disorders can inform nosology and encourages the investigation of common pathophysiologies for related disorders.
Keyword Attention-Deficit/hyperactivity Disorder
Deficit Hyperactivity Disorder
Autism Spectrum Disorders
Major Depressive Disorder
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID FT0991360
DE130100614
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2014 Collection
UQ Diamantina Institute Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 649 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 803 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sun, 22 Sep 2013, 10:12:57 EST by System User on behalf of Queensland Brain Institute