Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases

Munoz-Price, L. Silvia, Poirel, Laurent, Bonomo, Robert A., Schwaber, Mitchell J., Daikos, George L., Cormican, Martin, Cornaglia, Giuseppe, Garau, Javier, Gniadkowski, Marek, Hayden, Mary K., Kumarasamy, Karthikeyan, Livermore, David M., Maya, Juan J., Nordmann, Patrice, Patel, Jean B., Paterson, David L., Pitout, Johann, Villegas, Maria Virginia, Wang, Hui, Woodford, Neil and Quinn, John P. (2013) Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases. Lancet Infectious Diseases, 13 9: 785-796. doi:10.1016/S1473-3099(13)70190-7


Author Munoz-Price, L. Silvia
Poirel, Laurent
Bonomo, Robert A.
Schwaber, Mitchell J.
Daikos, George L.
Cormican, Martin
Cornaglia, Giuseppe
Garau, Javier
Gniadkowski, Marek
Hayden, Mary K.
Kumarasamy, Karthikeyan
Livermore, David M.
Maya, Juan J.
Nordmann, Patrice
Patel, Jean B.
Paterson, David L.
Pitout, Johann
Villegas, Maria Virginia
Wang, Hui
Woodford, Neil
Quinn, John P.
Title Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases
Formatted title
Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases
Journal name Lancet Infectious Diseases   Check publisher's open access policy
ISSN 1473-3099
1474-4457
Publication date 2013-09-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/S1473-3099(13)70190-7
Open Access Status DOI
Volume 13
Issue 9
Start page 785
End page 796
Total pages 12
Place of publication London, United Kingdom
Publisher Lancet Publishing Group
Language eng
Subject 2725 Infectious Diseases
Abstract Klebsiella pneumoniae carbapenemases (KPCs) were originally identified in the USA in 1996. Since then, these versatile β-lactamases have spread internationally among Gram-negative bacteria, especially K pneumoniae, although their precise epidemiology is diverse across countries and regions. The mortality described among patients infected with organisms positive for KPC is high, perhaps as a result of the limited antibiotic options remaining (often colistin, tigecycline, or aminoglycosides). Triple drug combinations using colistin, tigecycline, and imipenem have recently been associated with improved survival among patients with bacteraemia. In this Review, we summarise the epidemiology of KPCs across continents, and discuss issues around detection, present antibiotic options and those in development, treatment outcome and mortality, and infection control. In view of the limitations of present treatments and the paucity of new drugs in the pipeline, infection control must be our primary defence for now.
Formatted abstract
Klebsiella pneumoniae carbapenemases (KPCs) were originally identified in the USA in 1996. Since then, these versatile β-lactamases have spread internationally among Gram-negative bacteria, especially K pneumoniae, although their precise epidemiology is diverse across countries and regions. The mortality described among patients infected with organisms positive for KPC is high, perhaps as a result of the limited antibiotic options remaining (often colistin, tigecycline, or aminoglycosides). Triple drug combinations using colistin, tigecycline, and imipenem have recently been associated with improved survival among patients with bacteraemia. In this Review, we summarise the epidemiology of KPCs across continents, and discuss issues around detection, present antibiotic options and those in development, treatment outcome and mortality, and infection control. In view of the limitations of present treatments and the paucity of new drugs in the pipeline, infection control must be our primary defence for now.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: UQ Centre for Clinical Research Publications
Official 2014 Collection
 
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