Caveola-forming proteins caveolin‑1 and PTRF in prostate cancer

Nassar, Zeyad D., Hill, Michelle M., Parton, Robert G. and Parat, Marie-Odile (2013) Caveola-forming proteins caveolin‑1 and PTRF in prostate cancer. Nature Reviews Urology, 10 9: 529-536. doi:10.1038/nrurol.2013.168

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Author Nassar, Zeyad D.
Hill, Michelle M.
Parton, Robert G.
Parat, Marie-Odile
Title Caveola-forming proteins caveolin‑1 and PTRF in prostate cancer
Journal name Nature Reviews Urology   Check publisher's open access policy
ISSN 1759-4812
1759-4820
Publication date 2013-08-13
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/nrurol.2013.168
Volume 10
Issue 9
Start page 529
End page 536
Total pages 8
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Formatted abstract
The expression of caveola-forming proteins is dysregulated in prostate cancer. Caveolae are flask-shaped invaginations of the plasma membrane that have roles in membrane trafficking and cell signalling. Members of two families of proteins—caveolins and cavins—are known to be required for the formation and functions of caveolae. Caveolin-1, the major structural protein of caveolae, is overexpresssed in prostate cancer and has been demonstrated to be involved in prostate cancer angiogenesis, growth and metastasis. Polymerase I and transcript release factor (PTRF) is the only cavin family member necessary for caveola formation. When exogenously expressed in prostate cancer cells, PTRF reduces aggressive potential, probably via both caveola-mediated and caveola-independent mechanisms. In addition, stromal PTRF expression decreases with progression of the disease. Evaluation of caveolin-1 antibodies in the clinical setting is underway and it is hoped that future studies will reveal the mechanisms of PTRF action, allowing its targeting for therapeutic purposes.

Key points
> Caveolae are flask-shaped plasma membrane invaginations, the formation of which requires two families of proteins, the membrane-inserted caveolins and cytoplasmic cavins
> Caveolin-1, the major caveolin family member, is overexpressed in prostate cancer and promotes tumour growth, angiogenesis and insensitivity to androgen deprivation
> Caveolin-1 can be secreted and exert paracrine and endocrine effects that contribute to prostate tumour growth and metastasis
> Expression of polymerase I and transcript release factor (PTRF) is reported to be absent in prostate cancer
> Exogenous expression of PTRF reduces prostate cancer aggressiveness probably via both caveola-mediated and caveola-independent mechanisms
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online 13 August 2013

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2014 Collection
School of Pharmacy Publications
Institute for Molecular Bioscience - Publications
Centre for Microscopy and Microanalysis Publications
UQ Diamantina Institute Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 24 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 19 Sep 2013, 01:26:32 EST by Myrtle Sahabandu on behalf of School of Pharmacy