Epigenetic regulation of mouse sex determination by the histone demethylase Jmjd1a

Kuroki, Shunsuke, Matoba, Shogo, Akiyoshi, Mika, Matsumara, Yasuko, Miyachi, Hitoshi, Mise, Nathan, Abe, Kuniya, Ogura, Atsuo, Wilhelm, Dagmar, Koopman, Peter, Nozaki, Masami, Kanai, Yoshiakira, Shinkai, Yoichi and Tachibana, Makoto (2013) Epigenetic regulation of mouse sex determination by the histone demethylase Jmjd1a. Science, 341 6150: 1106-1109. doi:10.1126/science.1239864

Author Kuroki, Shunsuke
Matoba, Shogo
Akiyoshi, Mika
Matsumara, Yasuko
Miyachi, Hitoshi
Mise, Nathan
Abe, Kuniya
Ogura, Atsuo
Wilhelm, Dagmar
Koopman, Peter
Nozaki, Masami
Kanai, Yoshiakira
Shinkai, Yoichi
Tachibana, Makoto
Title Epigenetic regulation of mouse sex determination by the histone demethylase Jmjd1a
Journal name Science   Check publisher's open access policy
ISSN 0036-8075
Publication date 2013-09-06
Year available 2013
Sub-type Article (original research)
DOI 10.1126/science.1239864
Volume 341
Issue 6150
Start page 1106
End page 1109
Total pages 4
Place of publication Washington, DC, United States
Publisher American Association for the Advancement of Science
Language eng
Formatted abstract
Developmental gene expression is defined through cross-talk between the function of transcription factors and epigenetic status, including histone modification. Although several transcription factors play crucial roles in mammalian sex determination, how epigenetic regulation contributes to this process remains unknown. We observed male-to-female sex reversal in mice lacking the H3K9 demethylase Jmjd1a and found that Jmjd1a regulates expression of the mammalian Y chromosome sex-determining gene Sry. Jmjd1a directly and positively controls Sry expression by regulating H3K9me2 marks. These studies reveal a pivotal role of histone demethylation in mammalian sex determination.
Keyword Multidisciplinary Sciences
Science & Technology - Other Topics
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 65 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 70 times in Scopus Article | Citations
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Created: Wed, 18 Sep 2013, 01:00:45 EST by Susan Allen on behalf of Institute for Molecular Bioscience