Physical clustering of FLC alleles during Polycomb-mediated epigenetic silencing in vernalization

Rosa, Stefanie, De Lucia, Filomena, Mylne, Joshua S., Zhu, Danling, Ohmido, Nobuko, Pendle, Ali, Kato, Naohiro, Shaw, Peter and Dean, Caroline (2013) Physical clustering of FLC alleles during Polycomb-mediated epigenetic silencing in vernalization. Genes and Development, 27 17: 1845-1850. doi:10.1101/gad.221713.113


Author Rosa, Stefanie
De Lucia, Filomena
Mylne, Joshua S.
Zhu, Danling
Ohmido, Nobuko
Pendle, Ali
Kato, Naohiro
Shaw, Peter
Dean, Caroline
Title Physical clustering of FLC alleles during Polycomb-mediated epigenetic silencing in vernalization
Formatted title
Physical clustering of FLC alleles during Polycomb-mediated epigenetic silencing in vernalization
Journal name Genes and Development   Check publisher's open access policy
ISSN 0890-9369
1549-5477
Publication date 2013-09-01
Sub-type Article (original research)
DOI 10.1101/gad.221713.113
Open Access Status DOI
Volume 27
Issue 17
Start page 1845
End page 1850
Total pages 6
Place of publication Woodbury, NY, United States
Publisher Cold Spring Harbor Laboratory Press
Collection year 2014
Language eng
Formatted abstract
Vernalization, the promotion of flowering by cold, involves Polycomb-mediated epigenetic silencing of FLOWERING LOCUS C (FLC). Cold progressively promotes cell-autonomous switching to a silenced state. Here, we used live-cell imaging of FLC-lacO to monitor changes in nuclear organization during vernalization. FLC-lacO alleles physically cluster during the cold and generally remain so after plants are returned to warm. Clustering is dependent on the Polycomb trans-factors necessary for establishment of the FLC silenced state but not on LIKE HETEROCHROMATIN PROTEIN 1, which functions to maintain silencing. These data support the view that physical clustering may be a common feature of Polycomb-mediated epigenetic switching mechanisms.
Keyword Nuclear organization
Epigenetic
FLC
Vernalization
Polycomb
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
Institute for Molecular Bioscience - Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 31 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 35 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 17 Sep 2013, 22:36:50 EST by Susan Allen on behalf of Institute for Molecular Bioscience