The application of emerging technologies in genomics and proteomics to drug development

Mahler, S. M., Chin, D. Y. and Van Dyk, D. D. (2003) The application of emerging technologies in genomics and proteomics to drug development. Journal of Pharmacy Practice and Research, 33 1: 7-11.

Author Mahler, S. M.
Chin, D. Y.
Van Dyk, D. D.
Title The application of emerging technologies in genomics and proteomics to drug development
Journal name Journal of Pharmacy Practice and Research   Check publisher's open access policy
ISSN 1445-937X
Publication date 2003-03-01
Year available 2003
Sub-type Article (original research)
Open Access Status Not Open Access
Volume 33
Issue 1
Start page 7
End page 11
Total pages 5
Place of publication Collingwood, VIC Australia
Publisher Society of Hospital Pharmacists of Australia
Language eng
Formatted abstract
The completion of the first draft of the Human Genome Project and the emerging discipline of proteomics will have a major impact on the future and practice of pharmacy and medicine in the longer-term. The identification of single nucleotide polymorphisms within the human genome and especially those within genes will contribute to the elucidation of disease and disease processes, and to profiling individual drug response and susceptibility to drug side effects. New drug targets will be discovered principally through proteomic techniques such as two-dimensional gel electrophoresis, liquid chromatography and mass spectrometry. The creation of large libraries of synthetic compounds and natural products from rain forests, coral reefs and other biologically significant ecosystems, the development of high-throughput screening tools by pharmaceutical companies and the discovery of new targets through proteomics will ensure a surge in new drug development. Through pharmacogenomics, the hope is that treatment of patients may be fine-tuned according to their genetic make-up and profile, to maximise therapeutic efficacy while minimising side effects. The future development and refinement of proteomic techniques will be central for these outcomes in drug development to come to fruition.
Keyword Drug development
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Australian Institute for Bioengineering and Nanotechnology Publications
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Created: Tue, 10 Sep 2013, 00:19:40 EST by Cathy Fouhy on behalf of Aust Institute for Bioengineering & Nanotechnology