A Pig Model of the Preterm Neonate: Anthropometric and Physiological Characteristics

Eiby, Yvonne A., Wright, Layne L., Kalanjati, Viskasari P., Miller, Stephanie M., Bjorkman, Stella T., Keates, Helen L., Lumbers, Eugenie R., Colditz, Paul B. and Lingwood, Barbara E. (2013) A Pig Model of the Preterm Neonate: Anthropometric and Physiological Characteristics. PLoS ONE, 8 7: . doi:10.1371/journal.pone.0068763


Author Eiby, Yvonne A.
Wright, Layne L.
Kalanjati, Viskasari P.
Miller, Stephanie M.
Bjorkman, Stella T.
Keates, Helen L.
Lumbers, Eugenie R.
Colditz, Paul B.
Lingwood, Barbara E.
Title A Pig Model of the Preterm Neonate: Anthropometric and Physiological Characteristics
Journal name PLoS ONE   Check publisher's open access policy
ISSN 1932-6203
Publication date 2013-07-01
Year available 2013
Sub-type Article (original research)
DOI 10.1371/journal.pone.0068763
Open Access Status DOI
Volume 8
Issue 7
Total pages 8
Place of publication San Francisco, CA United States
Publisher Public Library of Science
Language eng
Formatted abstract
Background:Large animal models are an essential tool in the development of rationally-based new clinical therapies for preterm infants. We provide a description of the newborn pig as a model of the preterm neonate in terms of growth parameters, physiology and the requirement for intensive care over a range of gestational ages.

Methods:Twenty-nine litters of piglets (n = 298) were delivered by caesarean section at six timepoints during gestation from 91d to 113d (term = 115d). Two groups, at 91 and 97d gestation, also received maternal glucocorticoid treatment. At four of these timepoints, piglets (n = 79) were ventilated, sedated and monitored using standard neonatal intensive care techniques for up to 8 h in various experimental protocols.

Results:Body weight increased from mean 697 g (SD 193) at 91d gestation to 1331 g (SD 368) at 113d gestation. Piglets delivered at 97d gestation were able to be resuscitated and kept alive for at least 8 h on respiratory support after surfactant administration. Maternal glucocorticoid treatment 48 h and 24 h hours prior to delivery reduced the requirement for ventilator support and improved cardiovascular stability.

Conclusion:The pig provides a relevant model for the study of human preterm physiology and for investigation of novel therapies to improve outcomes.
Keyword Intrauterine Growth Restriction
Fetal Sheep
Necrotizing Enterocolitis
Immature Baboons
Newborn Piglets
Brain Growth
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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