Introgression and the fate of domesticated genes in a wild mammal population

Feulner, Philine G. D., Gratten, Jacob, Kijas, James W., Visscher, Peter M., Pemberton, Josephine M. and Slate, Jon (2013) Introgression and the fate of domesticated genes in a wild mammal population. Molecular Ecology, 22 16: 4210-4221. doi:10.1111/mec.12378

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Author Feulner, Philine G. D.
Gratten, Jacob
Kijas, James W.
Visscher, Peter M.
Pemberton, Josephine M.
Slate, Jon
Title Introgression and the fate of domesticated genes in a wild mammal population
Journal name Molecular Ecology   Check publisher's open access policy
ISSN 0962-1083
Publication date 2013-08-01
Year available 2013
Sub-type Article (original research)
DOI 10.1111/mec.12378
Open Access Status DOI
Volume 22
Issue 16
Start page 4210
End page 4221
Total pages 12
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell
Language eng
Subject 1105 Ecology, Evolution, Behavior and Systematics
1311 Genetics
Abstract When domesticated species are not reproductively isolated from their wild relatives, the opportunity arises for artificially selected variants to be re-introduced into the wild. However, the evolutionary consequences of introgression of domesticated genes back into the wild are poorly understood. By combining high-throughput genotyping with 25 years of long-term ecological field data, we describe the occurrence and consequences of admixture between a primitive sheep breed, the free-living Soay sheep of St Kilda, and more modern breeds. Utilizing data from a 50 K ovine SNP chip, together with forward simulations of demographic scenarios, we show that admixture occurred between Soay sheep and a more modern breed, consistent with historical accounts, approximately 150 years ago. Haplotype-sharing analyses with other breeds revealed that polymorphisms in coat colour and pattern in Soay sheep arose as a result of introgression of genetic variants favoured by artificial selection. Because the haplotypes carrying the causative mutations are known to be under natural selection in free-living Soay sheep, the admixture event created an opportunity to observe the outcome of a 'natural laboratory' experiment where ancestral and domesticated genes competed with each other. The haplotype carrying the domesticated light coat colour allele was favoured by natural selection, while the haplotype associated with the domesticated self coat pattern allele was associated with decreased survival. Therefore, we demonstrate that introgression of domesticated alleles into wild populations can provide a novel source of variation capable of generating rapid evolutionary changes.
Keyword Adaptive introgression
Domesticated alleles
Natural selection
Soay sheep
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 42815
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
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UQ Diamantina Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 21 times in Thomson Reuters Web of Science Article | Citations
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