Regulation of AMPA receptor function by the human memory-associated gene KIBRA

Makuch, Lauren, Volk, Lenora, Anggono, Victor, Johnson, Richard C., Yu, Yilin, Duning, Kerstin, Kremerskothen, Joachim, Xia, Jun, Takamiya, Kogo and Huganir, Richard L. (2011) Regulation of AMPA receptor function by the human memory-associated gene KIBRA. Neuron, 71 6: 1022-1029. doi:10.1016/j.neuron.2011.08.017

Author Makuch, Lauren
Volk, Lenora
Anggono, Victor
Johnson, Richard C.
Yu, Yilin
Duning, Kerstin
Kremerskothen, Joachim
Xia, Jun
Takamiya, Kogo
Huganir, Richard L.
Title Regulation of AMPA receptor function by the human memory-associated gene KIBRA
Journal name Neuron   Check publisher's open access policy
ISSN 0896-6273
Publication date 2011-09-01
Year available 2011
Sub-type Article (original research)
DOI 10.1016/j.neuron.2011.08.017
Open Access Status DOI
Volume 71
Issue 6
Start page 1022
End page 1029
Total pages 8
Place of publication Cambridge, United States
Publisher Cell Press
Language eng
Formatted abstract
KIBRA has recently been identified as a gene associated with human memory performance. Despite the elucidation of the role of KIBRA in several diverse processes in nonneuronal cells, the molecular function of KIBRA in neurons is unknown. We found that KIBRA directly binds to the protein interacting with C-kinase 1 (PICK1) and forms a complex with α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptors (AMPARs), the major excitatory neurotransmitter receptors in the brain. KIBRA knockdown accelerates the rate of AMPAR recycling following N-methyl-D-aspartate receptor-induced internalization. Genetic deletion of KIBRA in mice impairs both long-term depression and long-term potentiation at hippocampal Schaffer collateral-CA1 synapses. Moreover, KIBRA knockout mice have severe deficits in contextual fear learning and memory. These results indicate that KIBRA regulates higher brain function by regulating AMPAR trafficking and synaptic plasticity.
Keyword Domain-containing protein
Long-term depression
Synaptic plasticity
Episodic memory
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID MH64856
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
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