Intestinal Ferritin H Is Required for an Accurate Control of Iron Absorption

Vanoaica, Liviu, Darshan, Deepak, Richman, Larry, Schuemann, Klaus and Kuehn, Lukas C. (2010) Intestinal Ferritin H Is Required for an Accurate Control of Iron Absorption. Cell Metabolism, 12 3: 273-282. doi:10.1016/j.cmet.2010.08.003


Author Vanoaica, Liviu
Darshan, Deepak
Richman, Larry
Schuemann, Klaus
Kuehn, Lukas C.
Title Intestinal Ferritin H Is Required for an Accurate Control of Iron Absorption
Journal name Cell Metabolism   Check publisher's open access policy
ISSN 1550-4131
1932-7420
Publication date 2010-09-01
Year available 2010
Sub-type Article (original research)
DOI 10.1016/j.cmet.2010.08.003
Open Access Status Not yet assessed
Volume 12
Issue 3
Start page 273
End page 282
Total pages 10
Place of publication Cambridge, MA United States
Publisher Cell Press
Language eng
Formatted abstract
To maintain appropriate body iron levels, iron absorption by the proximal duodenum is thought to be controlled by hepcidin, a polypeptide secreted by hepatocytes in response to high serum iron. Hepcidin limits basolateral iron efflux from the duodenal epithelium by binding and downregulating the intestinal iron exporter ferroportin. Here, we found that mice with an intestinal ferritin H gene deletion show increased body iron stores and transferrin saturation. As expected for iron-loaded animals, the ferritin H-deleted mice showed induced liver hepcidin mRNA levels and reduced duodenal expression of DMT1 and DcytB mRNA. In spite of these feedback controls, intestinal ferroportin protein and 59Fe absorption were increased more than 2-fold in the deleted mice. Our results demonstrate that hepcidin-mediated regulation alone is insufficient to restrict iron absorption and that intestinal ferritin H is also required to limit iron efflux from intestinal cells 
Keyword Antimicrobial Peptide Hepcidin
Messenger Rna
Hereditary Hemochromatosis
Juvenile Hemochromatosis
Transferrin Receptor
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 3100A0-109865
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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