Axon position within the corpus callosum determines contralateral cortical projection

Zhou, Jing, Wen, Yunqing, She, Liang, Sui, Ya-nan, Liu, Lu, Richards, Linda J. and Poo, Mu-ming (2013) Axon position within the corpus callosum determines contralateral cortical projection. Proceedings of the National Academy of Sciences of the United States of America, 110 29: E2714-E2723. doi:10.1073/pnas.1310233110


Author Zhou, Jing
Wen, Yunqing
She, Liang
Sui, Ya-nan
Liu, Lu
Richards, Linda J.
Poo, Mu-ming
Title Axon position within the corpus callosum determines contralateral cortical projection
Journal name Proceedings of the National Academy of Sciences of the United States of America   Check publisher's open access policy
ISSN 0027-8424
1091-6490
Publication date 2013-07-01
Year available 2013
Sub-type Article (original research)
DOI 10.1073/pnas.1310233110
Open Access Status Not yet assessed
Volume 110
Issue 29
Start page E2714
End page E2723
Total pages 10
Place of publication Washington, DC United States
Publisher National Academy of Sciences
Language eng
Abstract How developing axons in the corpus callosum (CC) achieve their homotopic projection to the contralateral cortex remains unclear. We found that axonal position within the CC plays a critical role in this projection. Labeling of nearby callosal axons in mice showed that callosal axons were segregated in an orderly fashion, with those from more medial cerebral cortex located more dorsally and subsequently projecting to more medial contralateral cortical regions. The normal axonal order within the CC was grossly disturbed when semaphorin3A/neuropilin-1 signaling was disrupted. However, the order in which axons were positioned within the CC still determined their contralateral projection, causing a severe disruption of the homotopic contralateral projection that persisted at postnatal day 30, when the normal developmental refinement of contralateral projections is completed in wild-type (WT) mice. Thus, the orderly positioning of axons within the CC is a primary determinant of how homotopic interhemispheric projections form in the contralateral cortex.
Formatted abstract
How developing axons in the corpus callosum (CC) achieve their homotopic projection to the contralateral cortex remains unclear.We found that axonal position within the CC plays a critical role in this projection. Labeling of nearby callosal axons in mice showed that callosal axons were segregated in an orderly fashion, with those from more medial cerebral cortex located more dorsally and subsequently projecting to more medial contralateral cortical regions. The normal axonal order within the CC was grossly disturbed when semaphorin3A/neuropilin-1 signaling was disrupted. However, the order in which axonswere positioned within the CC still determined their contralateral projection, causing a severe disruption of the homotopic contralateral projection that persisted at postnatal day 30, when the normal developmental refinement of contralateral projections is completed in wild-type (WT) mice. Thus, the orderly positioning of axons within the CC is a primary determinant of how homotopic interhemispheric projections form in the contralateral cortex.
Keyword Axon development
Axon fiber order
Cortical axon guidance
Cortical development
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 2011CBA00400
XDB02020001
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2014 Collection
School of Biomedical Sciences Publications
 
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