Research review: the role of cytokines in depression in adolescents: a systematic review

Mills, Natalie T., Scott, James G., Wray, Naomi R., Cohen-Woods, Sarah and Baune, Bernhard T. (2013) Research review: the role of cytokines in depression in adolescents: a systematic review. Journal of Child Psychology and Psychiatry, 54 8: 816-835. doi:10.1111/jcpp.12080

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Author Mills, Natalie T.
Scott, James G.
Wray, Naomi R.
Cohen-Woods, Sarah
Baune, Bernhard T.
Title Research review: the role of cytokines in depression in adolescents: a systematic review
Journal name Journal of Child Psychology and Psychiatry   Check publisher's open access policy
ISSN 0021-9630
1469-7610
Publication date 2013-08-01
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/jcpp.12080
Open Access Status File (Author Post-print)
Volume 54
Issue 8
Start page 816
End page 835
Total pages 20
Place of publication United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Abstract Background: While cytokines have been implicated in the pathophysiology of depression in adults, the potential role in younger age groups such as adolescents is less clear. This article therefore reviews the literature (a) to explore the relationship between cytokines and depression in adolescents, and (b) to examine how cytokines may be related to adolescent depression in the context of other neurobiological theories of depression. Method: A systematic review of the scientific literature on the subject was conducted in February 2013, searching the Web of Knowledge, PubMed (Medline), PsycInfo and Cochrane electronic databases. Results: Eighteen studies were identified measuring both depression or depressive symptoms and cytokines or immune markers in adolescents. Adolescents with depression show age-specific characteristics of the immune and inflammatory system, specifically in NK cell activity and in pro-inflammatory cytokines (such as IL-1 beta and TNF-alpha). In addition, the role of cytokines in adolescent depression is influenced by neurodevelopment, hormonal changes, stress and trauma. Conclusions: There may be differences in the neurobiology of adolescent major depressive disorder (MDD) compared with adult MDD. Increased understanding of the role of cytokines in adolescent MDD may lead to improved outcomes in the treatment of adolescent depression.
Formatted abstract
Background While cytokines have been implicated in the pathophysiology of depression in adults, the potential role in younger age groups such as adolescents is less clear. This article therefore reviews the literature (a) to explore the relationship between cytokines and depression in adolescents, and (b) to examine how cytokines may be related to adolescent depression in the context of other neurobiological theories of depression.

Method A systematic review of the scientific literature on the subject was conducted in February 2013, searching the Web of Knowledge, PubMed (Medline), PsycInfo and Cochrane electronic databases.

Results Eighteen studies were identified measuring both depression or depressive symptoms and cytokines or immune markers in adolescents. Adolescents with depression show age-specific characteristics of the immune and inflammatory system, specifically in NK cell activity and in pro-inflammatory cytokines (such as IL-1β and TNF-α). In addition, the role of cytokines in adolescent depression is influenced by neurodevelopment, hormonal changes, stress and trauma.

Conclusions There may be differences in the neurobiology of adolescent major depressive disorder (MDD) compared with adult MDD. Increased understanding of the role of cytokines in adolescent MDD may lead to improved outcomes in the treatment of adolescent depression.
Keyword Cytokines
Inflammation
Immune system
MDD
Cognition
Stress
Tumor-necrosis-factor
C-reactive protein
Serotonin transporter gene
Adult-onset depression
Killer-cell-activity
Reuptake inhibitor therapy
Teenage suicide victims
Stressful life events
Plasma L-tryptophan
Major depression
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID FT0991360
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: UQ Centre for Clinical Research Publications
Queensland Brain Institute Publications
Official 2014 Collection
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 33 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 40 times in Scopus Article | Citations
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