Cutaneous Carcinoma of the Head and Neck with Clinical Features of Perineural Infiltration Treated with Radiotherapy

Lin, Charles, Tripcony, Lee, Keller, Jacqui, Poulsen, Michael and Dickie, Graeme (2013) Cutaneous Carcinoma of the Head and Neck with Clinical Features of Perineural Infiltration Treated with Radiotherapy. Clinical Oncology, 25 6: 362-367. doi:10.1016/j.clon.2013.02.001


Author Lin, Charles
Tripcony, Lee
Keller, Jacqui
Poulsen, Michael
Dickie, Graeme
Title Cutaneous Carcinoma of the Head and Neck with Clinical Features of Perineural Infiltration Treated with Radiotherapy
Journal name Clinical Oncology   Check publisher's open access policy
ISSN 0936-6555
1433-2981
Publication date 2013-06-01
Sub-type Article (original research)
DOI 10.1016/j.clon.2013.02.001
Open Access Status Not yet assessed
Volume 25
Issue 6
Start page 362
End page 367
Total pages 6
Place of publication London, England, U.K.
Publisher W.B. Saunders Co. Ltd.
Language eng
Subject 2730 Oncology
2741 Radiology Nuclear Medicine and imaging
Abstract Aims: To review the outcome of patients with non-melanomatous carcinoma of the skin of the head and neck with perineural infiltration (PNI) with clinical features treated with radiotherapy. Materials and methods: Between 1991 and 2004, 56 patients with non-melanomatous skin carcinoma with PNI with clinical features were identified from the institution's oncology database. All patients had radiotherapy as either definitive or adjuvant treatment. The factors that affected outcome were analysed. The primary end point was the 5 year relapse-free survival (RFS) from the time of diagnosis of PNI. Results: The overall 5 year RFS for the whole group was 48%. Squamous histology had a more unfavourable outcome than basal cell histology (5 year RFS: 39% versus 80%; P = 0.07). Tumours located in the distribution of the cranial nerves V1 and V2 had a worse outcome than tumours at other sites (5 year RFS: 33% versus 72%, P = 0.056). Those with multiple cranial nerve involvement did worse than those with single nerve involvement (27% versus 62%, P = 0.1). The pattern of relapse was predominantly local (87%), with a low rate (15%) of successful salvage. Conclusion: Radiotherapy with or without surgery is curative in about half head and neck cutaneous non-melanomatous carcinomas with clinical PNI. The frequent local failure suggests that improvements in local treatment are required.
Keyword Perineural infiltration
radiotherapy
skin carcinoma
surgery
Cell Carcinoma
Skin-Cancer
Invasion
Spread
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Health and Rehabilitation Sciences Publications
School of Medicine Publications
 
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