beta-lactamase production in key gram-negative pathogen isolates from the Arabian Peninsula

Zowawi, Hosam M., Balkhy, Hanan H., Walsh, Timothy R. and Paterson, David L. (2013) beta-lactamase production in key gram-negative pathogen isolates from the Arabian Peninsula. Clinical Microbiology Reviews, 26 3: 361-380. doi:10.1128/CMR.00096-12


Author Zowawi, Hosam M.
Balkhy, Hanan H.
Walsh, Timothy R.
Paterson, David L.
Title beta-lactamase production in key gram-negative pathogen isolates from the Arabian Peninsula
Formatted title
β-lactamase production in key gram-negative pathogen isolates from the Arabian Peninsula
Journal name Clinical Microbiology Reviews   Check publisher's open access policy
ISSN 0893-8512
1098-6618
1070-6305
Publication date 2013-07-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1128/CMR.00096-12
Open Access Status DOI
Volume 26
Issue 3
Start page 361
End page 380
Total pages 20
Place of publication United States
Publisher American Society for Microbiology
Collection year 2014
Language eng
Formatted abstract
Infections due to Gram-negative bacilli (GNB) are a leading cause of morbidity and mortality worldwide. The extent of antibiotic resistance in GNB in countries of the Gulf Cooperation Council (GCC), namely, Saudi Arabia, United Arab Emirates, Kuwait, Qatar, Oman, and Bahrain, has not been previously reviewed. These countries share a high prevalence of extended-spectrum-β-lactamase (ESBL)- and carbapenemase-producing GNB, most of which are associated with nosocomial infections. Well-known and widespread β-lactamases genes (such as those for CTX-M-15, OXA-48, and NDM-1) have found their way into isolates from the GCC states. However, less common and unique enzymes have also been identified. These include PER-7, GES-11, and PME-1. Several potential risk factors unique to the GCC states may have contributed to the emergence and spread of β-lactamases, including the unnecessary use of antibiotics and the large population of migrant workers, particularly from the Indian subcontinent. It is clear that active surveillance of antimicrobial resistance in the GCC states is urgently needed to address regional interventions that can contain the antimicrobial resistance issue.
Keyword Intensive-care-unit
Resistant acinetobacter-baumannii
Urinary-tract-infections
Antimicrobial susceptibility patterns
Growth-promoting antibiotics
Sultanate-of-oman
In-vitro activity
Extended-spectrum
Saudi-arabia
Klebsiella-pneumoniae
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: UQ Centre for Clinical Research Publications
Official 2014 Collection
 
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Citation counts: TR Web of Science Citation Count  Cited 36 times in Thomson Reuters Web of Science Article | Citations
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