Pitfalls of predicting complex traits from SNPs

Wray, Naomi R., Yang, Jian, Hayes, Ben J., Price, Alkes L., Goddard, Michael E. and Visscher, Peter M. (2013) Pitfalls of predicting complex traits from SNPs. Nature Reviews Genetics, 14 7: 507-515. doi:10.1038/nrg3457

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Author Wray, Naomi R.
Yang, Jian
Hayes, Ben J.
Price, Alkes L.
Goddard, Michael E.
Visscher, Peter M.
Title Pitfalls of predicting complex traits from SNPs
Journal name Nature Reviews Genetics   Check publisher's open access policy
ISSN 1471-0056
Publication date 2013-07-01
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/nrg3457
Open Access Status File (Author Post-print)
Volume 14
Issue 7
Start page 507
End page 515
Total pages 9
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Subject 1312 Molecular Biology
1311 Genetics
2716 Genetics (clinical)
Abstract The success of genome-wide association studies (GWASs) has led to increasing interest in making predictions of complex trait phenotypes, including disease, from genotype data. Rigorous assessment of the value of predictors is crucial before implementation. Here we discuss some of the limitations and pitfalls of prediction analysis and show how naive implementations can lead to severe bias and misinterpretation of results.
Keyword Genome-wide association
Risk prediction
Common SNPs
Natural selection
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID P01 CA055075
UL1 RR025005
R01 HG006399
R01 DK058845
R01 GM075091
R01 MH100141
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Queensland Brain Institute Publications
Official 2014 Collection
UQ Diamantina Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 188 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 195 times in Scopus Article | Citations
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