DNA evidence for strong genetic stability and increasing heritability of intelligence from age 7 to 12

Trzaskowski, M., Yang, J., Visscher, P. M. and Plomin, R. (2014) DNA evidence for strong genetic stability and increasing heritability of intelligence from age 7 to 12. Molecular Psychiatry, 19 3: 380-384. doi:10.1038/mp.2012.191


Author Trzaskowski, M.
Yang, J.
Visscher, P. M.
Plomin, R.
Title DNA evidence for strong genetic stability and increasing heritability of intelligence from age 7 to 12
Journal name Molecular Psychiatry   Check publisher's open access policy
ISSN 1359-4184
1476-5578
Publication date 2014-03-01
Year available 2013
Sub-type Article (original research)
DOI 10.1038/mp.2012.191
Open Access Status DOI
Volume 19
Issue 3
Start page 380
End page 384
Total pages 5
Place of publication London, United Kingdom
Publisher Nature Publishing
Language eng
Subject 1312 Molecular Biology
2804 Cellular and Molecular Neuroscience
2738 Psychiatry and Mental health
Abstract Two genetic findings from twin research have far-reaching implications for understanding individual differences in the development of brain function as indexed by general cognitive ability (g, aka intelligence): (1) The same genes affect g throughout development, even though (2) heritability increases. It is now possible to test these hypotheses using DNA alone. From 1.7 million DNA markers and g scores at ages 7 and 12 on 2875 children, the DNA genetic correlation from age 7 to 12 was 0.73, highly similar to the genetic correlation of 0.75 estimated from 6702 pairs of twins from the same sample. DNA-estimated heritabilities increased from 0.26 at age 7 to 0.45 at age 12; twin-estimated heritabilities also increased from 0.35 to 0.48. These DNA results confirm the results of twin studies indicating strong genetic stability but increasing heritability for g, despite mean changes in brain structure and function from childhood to adolescence.
Keyword Cognitive development
Genome-wide complex trait analysis (GCTA)
Intelligence
Twins
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID G0500079(73692)
G0901245
G19/2(78332)
HD044454
G19/2
295366
085475/B/08/Z
R01 HD044454
R01 HD046167
G0500079
HD046167
085475/Z/08/Z
Institutional Status UQ
Additional Notes Published online 29 January 2013

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2014 Collection
UQ Diamantina Institute Publications
 
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Created: Thu, 01 Aug 2013, 02:09:35 EST by Debra McMurtrie on behalf of Queensland Brain Institute