Increased adiposity and insulin correlates with the progressive suppression of pulsatile GH secretion during weight gain

Steyn, F. J., Xie, T. Y., Huang, L., Ngo, S. T., Veldhuis, J. D., Waters, M. J. and Chen, C. (2013) Increased adiposity and insulin correlates with the progressive suppression of pulsatile GH secretion during weight gain. Journal of Endocrinology, 218 2: 233-244. doi:10.1530/JOE-13-0084


Author Steyn, F. J.
Xie, T. Y.
Huang, L.
Ngo, S. T.
Veldhuis, J. D.
Waters, M. J.
Chen, C.
Title Increased adiposity and insulin correlates with the progressive suppression of pulsatile GH secretion during weight gain
Journal name Journal of Endocrinology   Check publisher's open access policy
ISSN 0022-0795
1479-6805
Publication date 2013-08-01
Sub-type Article (original research)
DOI 10.1530/JOE-13-0084
Volume 218
Issue 2
Start page 233
End page 244
Total pages 12
Place of publication Woodlands, Bristol, United Kingdom
Publisher BioScientifica
Language eng
Formatted abstract
Pathological changes associated with obesity are thought to contribute to GH deficiency. However, recent observations suggest that impaired GH secretion relative to excess calorie consumption contributes to progressive weight gain and thus may contribute to the development of obesity. To clarify this association between adiposity and GH secretion, we investigated the relationship between pulsatile GH secretion and body weight; epididymal fat mass; and circulating levels of leptin, insulin, non-esterified free fatty acids (NEFAs), and glucose. Data were obtained from male mice maintained on a standard or high-fat diet. We confirm the suppression of pulsatile GH secretion following dietary-induced weight gain. Correlation analyses reveal an inverse relationship between measures of pulsatile GH secretion, body weight, and epididymal fat mass. Moreover, we demonstrate an inverse relationship between measures of pulsatile GH secretion and circulating levels of leptin and insulin. The secretion of GH did not change relative to circulating levels of NEFAs or glucose. We conclude that impaired pulsatile GH secretion in the mouse occurs alongside progressive weight gain and thus precedes the development of obesity. Moreover, data illustrate key interactions between GH secretion and circulating levels of insulin and reflect the potential physiological role of GH in modulation of insulin-induced lipogenesis throughout positive energy balance.
Keyword Pulsatile GH secretion
Dietary-induced weight gain
Insulin
Non-esterified free fatty acids
Adiposity
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Wed, 31 Jul 2013, 01:12:31 EST by Mr Frederik Steyn on behalf of School of Biomedical Sciences