Body composition and fitness in the obesity paradox: body mass index alone does not tell the whole story

Lavie, Carl J., De Schutter, Alban, Patel, Dharmendrakumar A. and Milani, Richard V. (2013) Body composition and fitness in the obesity paradox: body mass index alone does not tell the whole story. Preventive Medicine, 57 1: 1-2. doi:10.1016/j.ypmed.2013.03.010

Author Lavie, Carl J.
De Schutter, Alban
Patel, Dharmendrakumar A.
Milani, Richard V.
Title Body composition and fitness in the obesity paradox: body mass index alone does not tell the whole story
Formatted title
Body composition and fitness in the obesity paradox—body mass index alone does not tell the whole story
Journal name Preventive Medicine   Check publisher's open access policy
ISSN 0091-7435
Publication date 2013-07-01
Sub-type Editorial
DOI 10.1016/j.ypmed.2013.03.010
Volume 57
Issue 1
Start page 1
End page 2
Total pages 2
Place of publication United States
Publisher Academic Press
Language eng
Formatted abstract
Overweight and obese patients have considerably higher prevalence of most of the major cardiovascular (CV) risk factors, including hypertension (HTN), dyslipidemia (especially high levels of triglycerides [TGs] and lower levels of high-density lipoprotein cholesterol [HDL-C]), type 2 diabetes mellitus (T2DM), and inflammation (especially high levels of C-reactive protein [CRP]) (Lavie et al., 2009a). Additionally, independent of arterial pressure, overweight/obese patients have higher prevalence of left ventricular structural abnormalities, including concentric remodeling and left ventricular hypertrophy, and a higher prevalence of both systolic and diastolic dysfunction (Lavie et al., 2007 and Lavie et al., 2009a). Not surprisingly, almost every CV disease is increased in the setting of overweightness and obesity, including coronary heart disease (CHD), heart failure (HF), atrial fibrillation and peripheral arterial disease (Lavie et al., 2009a). However, despite the adverse effects of overweightness and obesity to increase the prevalence of adverse CV risk factors and CV diseases, now numerous studies have indicated an “obesity paradox,” where overweight and obese patients with various CV diseases generally have a better short- and long-term prognosis than do their lean counterparts (De Schutter et al., 2013, Hamer and Stamatakis, 2013, Lavie et al., 2003, Lavie et al., 2007, Lavie et al., 2009a, Lavie et al., 2009b, Lavie et al., 2011, Lavie et al., 2012 and Lavie et al., 2013b). Although decades ago, this paradox was difficult for scientists and clinicians to accept, now this has been demonstrated in numerous studies and large meta-analyses, making the obesity paradox now difficult to deny...
Keyword Coronary-heart-disease
Cardiorespiratory fitness
Lean paradox
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Editorial
Collections: Non HERDC
School of Medicine Publications
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