Virus-like particles associated with brown muscle disease in Manila clam, Ruditapes philippinarum, in Arcachon Bay (France)

Dang, C., Gonzalez, P., Mesmer-Dudons, N., Bonami, J-R, Caill-Milly, N. and de Montaudouin, X. (2009) Virus-like particles associated with brown muscle disease in Manila clam, Ruditapes philippinarum, in Arcachon Bay (France). Journal of Fish Diseases, 32 7: 577-584. doi:10.1111/j.1365-2761.2009.01019.x


Author Dang, C.
Gonzalez, P.
Mesmer-Dudons, N.
Bonami, J-R
Caill-Milly, N.
de Montaudouin, X.
Title Virus-like particles associated with brown muscle disease in Manila clam, Ruditapes philippinarum, in Arcachon Bay (France)
Journal name Journal of Fish Diseases   Check publisher's open access policy
ISSN 0140-7775
1365-2761
Publication date 2009-07-01
Year available 2009
Sub-type Article (original research)
DOI 10.1111/j.1365-2761.2009.01019.x
Volume 32
Issue 7
Start page 577
End page 584
Total pages 8
Place of publication West Sussex, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Formatted abstract
Recently, Manila clam, Ruditapes philippinarum, populations have suffered mortalities in Arcachon Bay (SW France). Mortality was associated with extensive lesions of the posterior adductor muscle, which become progressively brown and calcified. Ultrastructural observations by transmission electron microscopy revealed tissue degradation with necrotized muscle fibres and granulocytomas. Unenveloped virus-like particles (VLPs) were detected in muscle, granulocytic, epithelial and rectal cells. VLPs were abundant in the extracellular space, in the cytoplasm (free or enclosed in vesicles) and in the nucleoplasm of granulocytes. Nuclei and mitochondria of granulocytes displayed changes which suggested reactive oxygen species production and apoptosis induction. VLPs exhibited an icosahedral structure with a diameter of 25 to 35 nm. These observations suggest that the VLPs could belong to the family Picornaviridae or the Parvoviridae.
Keyword Adductor muscle
Apoptosis
Brown muscle disease
Necrosis
Ruditapes philippinarum
Transmission electron microscopy
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Biological Sciences Publications
 
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Created: Thu, 25 Jul 2013, 01:02:45 EST by Dr Cecile Dang on behalf of School of Biological Sciences