Cell-based therapies for ocular inflammation

Forrester, John V., Steptoe, Raymond J., Klaska, Izabela P., Martin-Granados, Cristina, Dua, Harminder S., Degli-Esposti, Mariapia A. and Wikstrom, Matthew E. (2013) Cell-based therapies for ocular inflammation. Progress in Retinal and Eye Research, 35 82-101. doi:10.1016/j.preteyeres.2013.02.002

Author Forrester, John V.
Steptoe, Raymond J.
Klaska, Izabela P.
Martin-Granados, Cristina
Dua, Harminder S.
Degli-Esposti, Mariapia A.
Wikstrom, Matthew E.
Title Cell-based therapies for ocular inflammation
Journal name Progress in Retinal and Eye Research   Check publisher's open access policy
ISSN 1350-9462
Publication date 2013-07-01
Sub-type Article (original research)
DOI 10.1016/j.preteyeres.2013.02.002
Open Access Status Not Open Access
Volume 35
Start page 82
End page 101
Total pages 20
Place of publication United Kingdom
Publisher Pergamon
Language eng
Formatted abstract
Since the plasticity and the potential for re-programming cells has become widely accepted, there has been great interest in cell-based therapies. These are being applied to a range of diseases, not least ocular diseases, where it is assumed that there is a reduced risk of immune rejection although this may be more perceived than real. There are two broad classes of cell-based therapies: those aimed at restoring structure and function of specific tissues and cells; and those directed towards restoring immunological homeostasis by controlling the damaging effects of inflammatory disease. Stem cells of all types represent the first group and prototypically have been used with the aim of regenerating failing cells. In contrast, immune cells have been suggested as potential modulators of inflammation. However, there is functional overlap in these two applications, with some types of stem cells, such as mesenchymal stem cells, demonstrating a potent immunomodulatory effect. This review summarises recent information on cell based therapies for ocular disease, with special emphasis on ocular inflammatory disease, and explores current uses, potential and limitations.
Keyword Stem cells
Dendritic cells
T regulatory cells
Regulatory T-cells
Mesenchymal stem-cells
Experimental autoimmune uveoretinitis
Tolerogenic dendritic cells
Pigment epithelial-cells
Collagen-induced arthritis
Antigen-specific suppression
Interferon-alpha treatment
Cystoid macular edema
Interferon-alpha treatment
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
UQ Diamantina Institute Publications
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