PTL-1 regulates neuronal integrity and lifespan in C-elegans

Chew, Yee Lian, Fan, Xiaochen, Goetz, Juergen and Nicholas, Hannah R. (2013) PTL-1 regulates neuronal integrity and lifespan in C-elegans. Journal of Cell Science, 126 9: 2079-2091. doi:10.1242/jcs.jcs124404

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Author Chew, Yee Lian
Fan, Xiaochen
Goetz, Juergen
Nicholas, Hannah R.
Title PTL-1 regulates neuronal integrity and lifespan in C-elegans
Journal name Journal of Cell Science   Check publisher's open access policy
ISSN 0021-9533
Publication date 2013-05-01
Sub-type Article (original research)
DOI 10.1242/jcs.jcs124404
Open Access Status File (Publisher version)
Volume 126
Issue 9
Start page 2079
End page 2091
Total pages 13
Place of publication Cambridge, United Kingdom
Publisher The Company of Biologists
Language eng
Formatted abstract
Protein with tau-like repeats (PTL-1) is the sole Caenorhabditis elegans homolog of tau and MAP2, which are members of the mammalian family of microtubule-associated proteins (MAPs). In mammalian neurons, tau and MAP2 are segregated, with tau being mainly localised to the axon and MAP2 mainly to the dendrite. In particular, tau plays a crucial role in pathology, as elevated levels lead to the formation of tau aggregates in many neurodegenerative conditions including Alzheimer’s disease. We used PTL-1 in C. elegans to model the biological functions of a tau-like protein without the complication of functional redundancy that is observed among the mammalian MAPs. Our findings indicate that PTL-1 is important for the maintenance of neuronal health as animals age, as well as in the egulation of whole organism lifespan. In addition, gene dosage of PTL-1 is crucial because variations from wild-type levels are detrimental. We also observed that human tau is unable to robustly compensate for loss of PTL-1, although phenotypes observed in tau transgenic worms are dependent on the presence of endogenous PTL-1. Our data suggest that some of the effects of tau pathology result from the loss of physiological tau function and not solely from a toxic gain-of-function due to accumulation of tau.
Keyword Tau
Protein with tau-like repeats
Caenorhabditis elegans
Neurodegenerative diseases
Alzheimer's disease
Microtubule-Associated Protein
Nematode Caenorhabditis-Elegans
Mouse Model
Frontotemporal Dementia
Touch Sensitivity
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2014 Collection
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Citation counts: TR Web of Science Citation Count  Cited 16 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 18 times in Scopus Article | Citations
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