The effect of clozapine therapy on frontal lobe dysfunction in schizophrenia: neuropsychology and event-related potential measures

Schall, U, Catts, SV, Chaturvedi, S, Liebert, B, Redenbach, J, Karayanidis, F and Ward, PB (1998) The effect of clozapine therapy on frontal lobe dysfunction in schizophrenia: neuropsychology and event-related potential measures. International Journal of Neuropsychopharmacology, 1 1: 19-29. doi:10.1017/S146114579800100X


Author Schall, U
Catts, SV
Chaturvedi, S
Liebert, B
Redenbach, J
Karayanidis, F
Ward, PB
Title The effect of clozapine therapy on frontal lobe dysfunction in schizophrenia: neuropsychology and event-related potential measures
Journal name International Journal of Neuropsychopharmacology   Check publisher's open access policy
ISSN 1461-1457
Publication date 1998-07-01
Year available 1998
Sub-type Article (original research)
DOI 10.1017/S146114579800100X
Open Access Status DOI
Volume 1
Issue 1
Start page 19
End page 29
Total pages 11
Place of publication NEW YORK
Publisher CAMBRIDGE UNIV PRESS
Language eng
Abstract There are several reports that performance-based measures as well as symptom ratings improve with clozapine in patients with schizophrenia who previously responded poorly to typical neuroleptic treatment. It is not clear whether improved cognitive function following initiation of clozapine is simply related to relief of psychotic symptoms and extrapyramidal side-effects associated with prior use of typical neuroleptics, or reflects another dimension of the greater efficacy of clozapine compared with typical neuroleptics. To elucidate this issue and better specify the cognitive changes associated with use of clozapine, the authors have assessed cognitive function psychometrically and using event-related potentials (ERPs), pre- and 8-12 wk post-initiation of clozapine treatment. Patients were rated on the BPRS, the SAPS and the SANS and completed a number of tests tapping aspects of frontal lobe function. ERP recordings were conducted using an auditory task twice, which was repeated under passive and active attention conditions. It was found that clozapine differentially affects tests reflecting executive and planning function, and not stimulus-driven cognitive functions. The results were not consistent with the hypothesis that these effects were simply due to relief of medication side-effects but could be related to the D-1 receptor antagonist actions of clozapine.
Keyword schizophrenia
frontal lobe functions
neuropsychology
event-related potentials
clozapine
Card Sorting Test
Working Memory
Auditory-Discrimination
Mismatch Negativity
Prepulse Inhibition
Prefrontal Cortex
Planning Ability
Test-Performance
Verbal Fluency
Symptoms
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: ResearcherID Downloads - Archived
 
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