The amygdala and medial prefrontal cortex: partners in the fear circuit

Marek, Roger, Strobel, Cornelia, Bredy, Timothy W. and Sah, Pankaj (2013) The amygdala and medial prefrontal cortex: partners in the fear circuit. Journal of Physiology, 591 10: 2381-2391. doi:10.1113/jphysiol.2012.248575

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads

Author Marek, Roger
Strobel, Cornelia
Bredy, Timothy W.
Sah, Pankaj
Title The amygdala and medial prefrontal cortex: partners in the fear circuit
Journal name Journal of Physiology   Check publisher's open access policy
ISSN 0022-3751
Publication date 2013-05-01
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1113/jphysiol.2012.248575
Open Access Status DOI
Volume 591
Issue 10
Start page 2381
End page 2391
Total pages 11
Place of publication Chichester, West Sussex, United Kingdom
Publisher Wiley-Blackwell
Language eng
Abstract Fear conditioning and fear extinction are Pavlovian conditioning paradigms extensively used to study the mechanisms that underlie learning and memory formation. The neural circuits that mediate this learning are evolutionarily conserved, and seen in virtually all species from flies to humans. In mammals, the amygdala and medial prefrontal cortex are two structures that play a key role in the acquisition, consolidation and retrieval of fear memory, as well extinction of fear. These two regions have extensive bidirectional connections, and in recent years, the neural circuits that mediate fear learning and fear extinction are beginning to be elucidated. In this review, we provide an overview of our current understanding of the neural architecture within the amygdala and medial prefrontal cortex. We describe how sensory information is processed in these two structures and the neural circuits between them thought to mediate different aspects of fear learning. Finally, we discuss how changes in circuits within these structures may mediate fear responses following fear conditioning and extinction.
Keyword Long-Term Potentiation
Parvalbumin-Positive Interneurons
Lateral Amygdala
Conditioned Fear
Basolateral Amygdala
Prelimbic Cortex
Morphological Properties
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Queensland Brain Institute Publications
Official 2014 Collection
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 74 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 82 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sun, 23 Jun 2013, 10:02:20 EST by System User on behalf of Queensland Brain Institute