Acute myeloid leukemia, the 3q21q26 syndrome and diabetes insipidus: A case presentation

Curley, Cameron, Kennedy, Glen, Haughton, Anne, Love, Amanda, McCarthy, Catherine and Boyd, Andrew (2010) Acute myeloid leukemia, the 3q21q26 syndrome and diabetes insipidus: A case presentation. Asia-Pacific Journal of Clinical Oncology, 6 2: 77-79. doi:10.1111/j.1743-7563.2010.01285.x

Author Curley, Cameron
Kennedy, Glen
Haughton, Anne
Love, Amanda
McCarthy, Catherine
Boyd, Andrew
Title Acute myeloid leukemia, the 3q21q26 syndrome and diabetes insipidus: A case presentation
Journal name Asia-Pacific Journal of Clinical Oncology   Check publisher's open access policy
ISSN 1743-7555
Publication date 2010-06-01
Year available 2010
Sub-type Article (original research)
DOI 10.1111/j.1743-7563.2010.01285.x
Open Access Status
Volume 6
Issue 2
Start page 77
End page 79
Total pages 3
Place of publication West Sussex United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Formatted abstract
Diabetes insipidus (DI) is a rare presenting complication of acute myeloid leukaemia (AML). Typically, the combination of DI and AML is associated with structural abnormalities of the neurohypophysis. We present a case of AML and DI presenting without any abnormalities of the neurohypophysis on radiological scanning and with normal cerebrospinal fluid examination. The AML karyotype at presentation was characterized by the presence of a t(3; 3)(q21; q26) translocation and monosomy 7. After treatment with induction chemotherapy, the patient achieved a complete remission and his DI resolved. At subsequent AML relapse, characterized by a complex karyotype without the t(3; 3)(q21; q26) translocation or monosomy 7, DI did not recur. Our case provides clinical support to the hypothesis that the t(3; 3)(q21; q26) translocation and/or monosomy 7 in AML may directly result in dysregulation of transcription factors resulting in development of DI in AML patients.
Keyword 3q21q26 syndrome
Acute myeloid leukemia
Diabetes insipidus
High platelet count
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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