Multiple groups of endogenous betaretroviruses in mice, rats, and other mammals

Baillie, Gregory J., van de Lagemaat, Louie N., Baust, Corinna and Mager, Dixie L. (2004) Multiple groups of endogenous betaretroviruses in mice, rats, and other mammals. Journal of Virology, 78 11: 5784-5798. doi:10.1128/JVI.78.11.5784-5798.2004

Author Baillie, Gregory J.
van de Lagemaat, Louie N.
Baust, Corinna
Mager, Dixie L.
Title Multiple groups of endogenous betaretroviruses in mice, rats, and other mammals
Journal name Journal of Virology   Check publisher's open access policy
ISSN 0022-538X
Publication date 2004-06-01
Year available 2004
Sub-type Article (original research)
DOI 10.1128/JVI.78.11.5784-5798.2004
Open Access Status DOI
Volume 78
Issue 11
Start page 5784
End page 5798
Total pages 15
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Language eng
Abstract Betaretroviruses exist in endogenous and exogenous forms in hosts that are widely distributed and evolutionarily distantly related. Here we report the discovery and characterization of several previously unknown betaretrovirus groups in the genomes of Mus musculus and Rattus norvegicus. Each group contains both mouse and rat elements, and several of the groups are more closely related to previously known betaretroviruses from nonmurine hosts. Some of the groups also include members from hosts which were not previously known to harbor betaretroviruses, such as the gray mouse lemur (Microcebus murinus) and Seba's short-tailed bat (Carollia perspicillata). Some of the mouse and rat elements possess intact open reading frames for gag, pro, pol, and/or env genes and display characteristics of having retrotransposed recently. We propose a model whereby betaretroviruses have been evolving within the genomes of murid rodents for at least the last 20 million years and, subsequent to (or concomitant with) the global spread of their murid hosts, have occasionally been transmitted to other species.
Keyword Virology
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 50 times in Thomson Reuters Web of Science Article | Citations
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Created: Fri, 14 Jun 2013, 21:22:08 EST by Gregory Baillie on behalf of Institute for Molecular Bioscience