Evolution of equine influenza virus in vaccinated horses

Murcia, Pablo R., Baillie, Gregory J., Stack, J. Conrad, Jervis, Carley, Elton, Debra, Mumford, Jennifer A., Daly, Janet, Kellam, Paul, Grenfell, Bryan T., Holmes, Edward C. and Wood, James L. N. (2013) Evolution of equine influenza virus in vaccinated horses. Journal of Virology, 87 8: 4768-4771. doi:10.1128/JVI.03379-12

Author Murcia, Pablo R.
Baillie, Gregory J.
Stack, J. Conrad
Jervis, Carley
Elton, Debra
Mumford, Jennifer A.
Daly, Janet
Kellam, Paul
Grenfell, Bryan T.
Holmes, Edward C.
Wood, James L. N.
Title Evolution of equine influenza virus in vaccinated horses
Journal name Journal of Virology   Check publisher's open access policy
ISSN 0022-538X
Publication date 2013-04-01
Year available 2013
Sub-type Article (original research)
DOI 10.1128/JVI.03379-12
Open Access Status DOI
Volume 87
Issue 8
Start page 4768
End page 4771
Total pages 4
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Language eng
Abstract Influenza A viruses are characterized by their ability to evade host immunity, even in vaccinated individuals. To determine how prior immunity shapes viral diversity in vivo, we studied the intra- and interhost evolution of equine influenza virus in vaccinated horses. Although the level and structure of genetic diversity were similar to those in naïve horses, intrahost bottlenecks may be more stringent in vaccinated animals, and mutations shared among horses often fall close to putative antigenic sites.
Keyword Virology
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID R01 GM080533-06
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 13 times in Thomson Reuters Web of Science Article | Citations
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Created: Fri, 14 Jun 2013, 21:15:08 EST by Gregory Baillie on behalf of Institute for Molecular Bioscience