SLC13 family of Na+-coupled di- and tri-carboxylate/sulfate transporters

Bergeron, M. J., Clemencon, B., Hediger, M. A. and Markovich, D. (2013) SLC13 family of Na+-coupled di- and tri-carboxylate/sulfate transporters. Molecular Aspects of Medicine, 34 2-3: 299-312. doi:10.1016/j.mam.2012.12.001


Author Bergeron, M. J.
Clemencon, B.
Hediger, M. A.
Markovich, D.
Title SLC13 family of Na+-coupled di- and tri-carboxylate/sulfate transporters
Formatted title
SLC13 family of Na+-coupled di- and tri-carboxylate/sulfate transporters
Journal name Molecular Aspects of Medicine   Check publisher's open access policy
ISSN 0098-2997
1872-9452
Publication date 2013-04-01
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.mam.2012.12.001
Open Access Status DOI
Volume 34
Issue 2-3
Start page 299
End page 312
Total pages 14
Place of publication Oxford, United Kingdom
Publisher Pergamon
Language eng
Subject 1303 Biochemistry
1312 Molecular Biology
1313 Molecular Medicine
1308 Clinical Biochemistry
2700 Medicine
Abstract The SLC13 family comprises five genes (SLC13A1, SLC13A2, SLC13A3, SLC13A4, and SLC13A5) encoding structurally related multi-spanning transporters (8-13 transmembrane domains) with orthologues found in prokaryotes and eukaryotes. Mammalian SLC13 members mediate the electrogenic Na-coupled anion cotransport at the plasma membrane of epithelial cells (mainly kidney, small intestine, placenta and liver) or cells of the central nervous system. While the two SLC13 cotransporters NaS1 (SLC13A1) and NaS2 (SLC13A4) transport anions such sulfate, selenate and thiosulfate, the three other SLC13 members, NaDC1 (SLC13A2), NaCT (SLC13A5) and NaDC3 (SLC13A3), transport di- and tri-carboxylate Krebs cycle intermediates such as succinate, citrate and α-ketoglutarate. All these transporters play a variety of physiological and pathophysiological roles in the different organs. Thus, the purpose of this review is to summarize the roles of SLC13 members in human physiology and pathophysiology and what the therapeutic perspectives are. We have also described the most recent advances on the structure, expression, function and regulation of SLC13 transporters.
Formatted abstract
The SLC13 family comprises five genes (SLC13A1, SLC13A2, SLC13A3, SLC13A4, and SLC13A5) encoding structurally related multi-spanning transporters (8–13 transmembrane domains) with orthologues found in prokaryotes and eukaryotes. Mammalian SLC13 members mediate the electrogenic Na+-coupled anion cotransport at the plasma membrane of epithelial cells (mainly kidney, small intestine, placenta and liver) or cells of the central nervous system. While the two SLC13 cotransporters NaS1 (SLC13A1) and NaS2 (SLC13A4) transport anions such sulfate, selenate and thiosulfate, the three other SLC13 members, NaDC1 (SLC13A2), NaCT (SLC13A5) and NaDC3 (SLC13A3), transport di- and tri-carboxylate Krebs cycle intermediates such as succinate, citrate and α-ketoglutarate. All these transporters play a variety of physiological and pathophysiological roles in the different organs. Thus, the purpose of this review is to summarize the roles of SLC13 members in human physiology and pathophysiology and what the therapeutic perspectives are. We have also described the most recent advances on the structure, expression, function and regulation of SLC13 transporters.
Keyword Dependent dicarboxylate transporter
Cotransporter gene Nas1
Sulfate renal transport
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published April–June 2013.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2014 Collection
School of Biomedical Sciences Publications
 
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