Treatment failure after percutaneous radiofrequency ablation for nonsurgical candidates with pulmonary metastases from colorectal carcinoma

Yan, Tristan D., King, Julie, Sjarif, Adrian, Glenn, Derek, Steinke, Karin, Al-Kindy, Ahmed and Morris, David L. (2007) Treatment failure after percutaneous radiofrequency ablation for nonsurgical candidates with pulmonary metastases from colorectal carcinoma. Annals of Surgical Oncology, 14 5: 1718-1726. doi:10.1245/s10434-006-9271-x


Author Yan, Tristan D.
King, Julie
Sjarif, Adrian
Glenn, Derek
Steinke, Karin
Al-Kindy, Ahmed
Morris, David L.
Title Treatment failure after percutaneous radiofrequency ablation for nonsurgical candidates with pulmonary metastases from colorectal carcinoma
Journal name Annals of Surgical Oncology   Check publisher's open access policy
ISSN 1068-9265
1534-4681
Publication date 2007-05-01
Year available 2007
Sub-type Article (original research)
DOI 10.1245/s10434-006-9271-x
Volume 14
Issue 5
Start page 1718
End page 1726
Total pages 9
Place of publication New York, NY United States
Publisher Springer
Language eng
Formatted abstract
Background: This study critically evaluated the local and overall treatment failure rates after percutaneous radiofrequency ablation (RFA) of pulmonary metastases from colorectal carcinoma.

Methods:
Fifty-five nonsurgical candidates underwent RFA of colorectal pulmonary metastases. The primary end points of this study were local progression-free survival (PFS) and overall PFS. Univariate and multivariate analyses were performed to identify significant prognostic parameters for local and overall PFS.

Results:
The local recurrence rate was 38%. For local PFS, univariate analysis demonstrated that the largest size of lung metastasis, the location of lung metastases, the post-RFA carcinoembryonic antigen level at 1 month, and the post-RFA carcinoembryonic antigen level at 3 months were significant prognostic indicators. In multivariate analysis, a largest size of lung metastasis of >3 cm and a post-RFA carcinoembryonic antigen level of >5 ng/mL at 1 month were independently associated with a reduced local PFS. The overall recurrence rate was 66%. For overall PFS, univariate analysis demonstrated that sex and the largest size of lung metastasis were significant prognostic indicators. In multivariate analysis, a largest size of lung metastasis of >3 cm was independently associated with a reduced overall PFS.

Conclusions: RFA of colorectal pulmonary metastases may have a useful role in local disease control for nonsurgical candidates, but its efficacy in patients with a lung metastasis of >3 cm is limited.
Keyword Radiofrequency ablation
Pulmonary Metastases
Colorectal carcinoma
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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