International recommendations on antiretroviral drugs for treatment of HIV-infected women and prevention of mother-to-child HIV transmission in resource-limited settings: 2006 update

Dao, Halima, Mofenson, Lynne M., Ekpini, Rene, Gilks, Charles F., Barnhart, Matthew, Bolu, Omotayo and Shaffer, Nathan (2007) International recommendations on antiretroviral drugs for treatment of HIV-infected women and prevention of mother-to-child HIV transmission in resource-limited settings: 2006 update. American Journal of Obstetrics and Gynecology, 197 3: S42-S55. doi:10.1016/j.ajog.2007.03.001


Author Dao, Halima
Mofenson, Lynne M.
Ekpini, Rene
Gilks, Charles F.
Barnhart, Matthew
Bolu, Omotayo
Shaffer, Nathan
Title International recommendations on antiretroviral drugs for treatment of HIV-infected women and prevention of mother-to-child HIV transmission in resource-limited settings: 2006 update
Journal name American Journal of Obstetrics and Gynecology   Check publisher's open access policy
ISSN 0002-9378
1097-6868
Publication date 2007-09-01
Sub-type Article (original research)
DOI 10.1016/j.ajog.2007.03.001
Volume 197
Issue 3
Start page S42
End page S55
Total pages 14
Place of publication Philadelphia, PA United States
Publisher Mosby
Collection year 2008
Language eng
Formatted abstract
The World Health Organization recommends that countries adopt more effective antiretroviral regimens to increase the effectiveness of the prevention of mother-to-child human immunodeficiency virus (HIV) transmission programs. The 2006 guidelines recommend a tiered approach for the delivery of antiretroviral to pregnant women who are infected with HIV and include triple-drug antiretroviral treatment for those women who are eligible. Those women who are not eligible for antiretroviral treatment should receive a combination prophylaxis antiretroviral regimen, preferably zidovudine from 28 weeks of gestation; zidovudine, lamivudine, and a single dose of nevirapine during delivery; and zidovudine and lamivudine for 7 days after delivery to reduce the development of nevirapine resistance. Newborn infants should receive a single dose of nevirapine and 1-4 weeks of zidovudine, depending on the duration of the regimen received by the mother. Although steps are being taken to provide more effective regimens, the use of single-dose nevirapine alone should still be used in situations in which more effective regimens are not yet feasible or available. HIV transmission through breastfeeding remains a problem, and several interventions are under evaluation that include maternal and/or infant antiretroviral prophylaxis during breastfeeding.
Keyword Antiretroviral
Hiv
Prevention of mother to child transmission
Single Dose Nevirapine
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Public Health Publications
 
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