Multiple Ciguatoxins in the Flesh of Fish

Lewis, RJ and Sellin, M (1992) Multiple Ciguatoxins in the Flesh of Fish. Toxicon, 30 8: 915-919. doi:10.1016/0041-0101(92)90390-Q


Author Lewis, RJ
Sellin, M
Title Multiple Ciguatoxins in the Flesh of Fish
Journal name Toxicon   Check publisher's open access policy
ISSN 0041-0101
Publication date 1992-08-01
Year available 1992
Sub-type Other
DOI 10.1016/0041-0101(92)90390-Q
Open Access Status DOI
Volume 30
Issue 8
Start page 915
End page 919
Total pages 5
Place of publication OXFORD
Publisher PERGAMON-ELSEVIER SCIENCE LTD
Language eng
Abstract Most cases of ciguatera (fish poisoning) result from consumption of the flesh of fishes contaminated with ciguatoxin(s); however, the relatively low toxicity of ciguateric fish flesh has hindered attempts to identify these ciguatoxin(s). Utilising high performance liquid chromatography, mass spectroscopy and mouse bioassay signs we have determined that ciguatoxin-1 (MH+ m/z = 1112), ciguatoxin-2 and ciguatoxin-3 are the major ciguatoxins present in the flesh of ciguateric fish. Ciguatoxin-1, -2 and -3 were present in yields of 0.19, 0.09 and 0.02-mu-g/kg flesh, respectively, in Scomberomorus commersoni, 0.08, 0.09 and 0.07-mu-g/kg flesh, respectively, in Plectropomus spp. and; 0.67, 0.61 and 0.06-mu-g/kg flesh, respectively, in Pomadasys maculatus. Two minor toxins, which may be further oxidised analogues of ciguatoxin-1 and ciguatoxin-2, were also identified. The presence of multiple ciguatoxins in fish flesh has important consequences for the detection of ciguateric fish and may be a contributing factor to the observed variability in the symptoms of ciguatera.
Keyword Gambierdiscus-Toxicus
Javanicus
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Other
Collection: ResearcherID Downloads - Archived
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 55 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 56 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 04 Jun 2013, 00:06:32 EST by System User