Alfaxalone and medetomidine intravenous infusion to maintain anaesthesia in colts undergoing field castration

Goodwin, W. A., Keates, H. L., Pearson, M. and Pasloske, K. (2013) Alfaxalone and medetomidine intravenous infusion to maintain anaesthesia in colts undergoing field castration. Equine Veterinary Journal, 45 3: 315-319. doi:10.1111/j.2042-3306.2012.00645.x

Author Goodwin, W. A.
Keates, H. L.
Pearson, M.
Pasloske, K.
Title Alfaxalone and medetomidine intravenous infusion to maintain anaesthesia in colts undergoing field castration
Journal name Equine Veterinary Journal   Check publisher's open access policy
ISSN 0425-1644
Publication date 2013-05-01
Year available 2013
Sub-type Article (original research)
DOI 10.1111/j.2042-3306.2012.00645.x
Volume 45
Issue 3
Start page 315
End page 319
Total pages 5
Place of publication Hoboken, NJ United States
Publisher John Wiley and Sons
Language eng
Formatted abstract
Reasons for performing the study: The use of alfaxalone and medetomidine administered as an i.v. infusion to maintain anaesthesia has not previously been reported in the horse. Objectives: To investigate the use of alfaxalone in hydroxpropyl-beta-cyclodextrin (Alfaxan) and medetomidine infusion as a field anaesthetic for short-term surgical procedures in the horse. Hypothesis: Alfaxalone-medetomidine anaesthesia is suitable for short-term field anaesthesia in horses. Methods: Eleven healthy colts underwent 45min of anaesthesia with an i.v. infusion of alfaxalone (2mg/kg bwt/h) and medetomidine (5μg/kg bwt/h) for routine field castration. Horses were premedicated with i.v. acepromazine (0.03mg/kg bwt), medetomidine (7μg/kg bwt) and guaiphenesin (35mg/kg bwt) before i.v. induction with alfaxalone (1mg/kg bwt). Colts were intubated with an endotracheal tube and 100% oxygen insufflated at 10l/min. The physiological variables monitored included pulse rate, respiratory rate, direct arterial blood pressure, arterial blood gases and the quality of the inductions and recoveries were scored. Results: Overall, the anaesthetic period and surgical conditions were acceptable and the quality of the anaesthetic inductions and recoveries was good to excellent. All colts stood on their first attempt (mean ± s.d.) 37 ± 13.5min after the infusion was stopped. During anaesthesia, cardiopulmonary data, presented as range of mean values at each time point were: heart rate: 45-47 beats/min; mean blood pressure: 104-112mmHg; respiratory rate: 8 breaths/min; PaO2: 117-172mmHg; PaCO2: 50-56mmHg and pH7.34-7.37. Conclusions and potential relevance: The co-administration of alfaxalone and medetomidine as an i.v. infusion after anaesthetic induction with alfaxalone was suitable for short-term field anaesthesia in the horse.
Keyword Horse
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
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