The regulation and functional impact of actin assembly at cadherin cell-cell adhesions

Magdalene, Michael and Yap, Alpha S. (2013) The regulation and functional impact of actin assembly at cadherin cell-cell adhesions. Seminars in Cell & Developmental Biology, 24 4: 298-307. doi:10.1016/j.semcdb.2012.12.004


Author Magdalene, Michael
Yap, Alpha S.
Title The regulation and functional impact of actin assembly at cadherin cell-cell adhesions
Journal name Seminars in Cell & Developmental Biology   Check publisher's open access policy
ISSN 1084-9521
1096-3634
Publication date 2013-04-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.semcdb.2012.12.004
Volume 24
Issue 4
Start page 298
End page 307
Total pages 10
Place of publication London, United Kingdom
Publisher Academic Press
Language eng
Abstract Cadherin adhesion receptors are critical components for the maintenance of tissue architecture and organisation during development and in post-embryonic life. These receptors influence the actin cytoskeletal network by controlling its assembly at the junctions. Likewise, the actin cytoskeleton is required for cadherin integrity at cell-cell contacts. The junctional cytoskeleton is intrinsically dynamic and undergoes constant assembly and reorganisation to maintain a morphologically stable structure. This is governed by a host of molecular players that regulate actin assembly during nucleation and at post-nucleation stages. This review highlights the molecular machinery implicated in actin organisation at various stages of junctional assembly and its functional impact in simple epithelia and other model systems.
Keyword Cadherins
Actin
Nucleation
Actin dynamics
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2014 Collection
Institute for Molecular Bioscience - Publications
 
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