Selective enhancement of motor cortical plasticity by observed mirror-matched actions

Sale, Martin V. and Mattingley, Jason B. (2013) Selective enhancement of motor cortical plasticity by observed mirror-matched actions. Neuroimage, 74 30-36. doi:10.1016/j.neuroimage.2013.02.009

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Author Sale, Martin V.
Mattingley, Jason B.
Title Selective enhancement of motor cortical plasticity by observed mirror-matched actions
Journal name Neuroimage   Check publisher's open access policy
ISSN 1053-8119
1095-9572
Publication date 2013-07-01
Sub-type Article (original research)
DOI 10.1016/j.neuroimage.2013.02.009
Open Access Status File (Author Post-print)
Volume 74
Start page 30
End page 36
Total pages 7
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Collection year 2014
Language eng
Abstract Watching others learn a motor task can enhance an observer's own later performance when learning the same motor task. This is thought to be due to activation of the action observation (or mirror neuron) network. Here we show that the effectiveness of plasticity induced in human motor cortex (M1) is also significantly influenced by the nature of prior action observation. In separate sessions, 17 participants watched a video showing repeated goal-directed movements (action observation) involving either the right hand (congruent condition) or the same video mirror-reversed to simulate the left hand (incongruent condition). Participants then received pulses of transcranial magnetic stimulation over the hand area of left M1 paired with median nerve stimulation of the right hand (paired associative stimulation; PAS). The resting motor-evoked potential (MEP) in right abductor pollicis brevis (APB) increased significantly 20. minutes after PAS, but only when participants had previously watched the congruent video. In this condition, all participants showed an increase in MEP amplitude at 20. minutes post-PAS. There was no change in MEP amplitude following PAS when participants watched the incongruent video. We conclude that prior action observation is a potent modulator of subsequent PAS-induced neuroplasticity, which may have important therapeutic applications.
Keyword Action observation
Mirror neurons
Neuroplasticity
Transcranial magnetic stimulation
Paired associative stimulation
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2014 Collection
School of Psychology Publications
 
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