Immunology of Anogenital Human Papillomavirus (Hpv) Infection

Tindle, RW and Frazer, IH (1990) Immunology of Anogenital Human Papillomavirus (Hpv) Infection. Australian & New Zealand Journal of Obstetrics & Gynaecology, 30 4: 370-375. doi:10.1111/j.1479-828X.1990.tb02033.x


Author Tindle, RW
Frazer, IH
Title Immunology of Anogenital Human Papillomavirus (Hpv) Infection
Journal name Australian & New Zealand Journal of Obstetrics & Gynaecology   Check publisher's open access policy
ISSN 0004-8666
Publication date 1990-11-01
Year available 1990
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/j.1479-828X.1990.tb02033.x
Open Access Status Not yet assessed
Volume 30
Issue 4
Start page 370
End page 375
Total pages 6
Place of publication EAST MELBOURNE VICTORIA
Publisher AUSTRALIAN NZ J OBSTET GYNAEC
Language eng
Abstract A subgroup of human papillomaviruses (HPVs) is implicated in the aetiology of neoplastic change in anogenital epithelium. Although abundant circumstantial evidence exists for the involvement of the immune system in the control of HPV infection, restriction of infection to epithelium and the lack of a viral productive phase pose problems for immune response induction, and for immunological effector mechanisms. In this article we discuss how HPV antigens may be presented to the immune system on the surface of keratinocytes as well as, or in addition to, presentation by 'classical' antigen presenting cells, and outline putative roles for non-specific and specific (B- and T- cell) effector functions. We discuss the prospects for a vaccine and the use of anti-HPV antibodies in immunodiagnosis.
Keyword Obstetrics & Gynecology
Obstetrics & Gynecology
OBSTETRICS & GYNECOLOGY
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: ResearcherID Downloads - Archived
 
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