Regulation of germ cell meiosis in the fetal ovary

Spiller, Cassy M., Bowles, Josephine and Koopman, Peter (2013) Regulation of germ cell meiosis in the fetal ovary. International Journal of Developmental Biology, 56 10-12: 779-787. doi:10.1387/ijdb.120142pk

Author Spiller, Cassy M.
Bowles, Josephine
Koopman, Peter
Title Regulation of germ cell meiosis in the fetal ovary
Journal name International Journal of Developmental Biology   Check publisher's open access policy
ISSN 0214-6282
Publication date 2013-02-05
Year available 2012
Sub-type Article (original research)
DOI 10.1387/ijdb.120142pk
Open Access Status Not yet assessed
Volume 56
Issue 10-12
Start page 779
End page 787
Total pages 9
Place of publication Bilbao, Spain
Publisher Universidad del Pais Vasco
Language eng
Abstract Fertility depends on correct regulation of meiosis, the special form of cell division that gives rise to haploid gametes. In female mammals, germ cells enter meiosis during fetal ovarian development, while germ cells in males avoid entering meiosis until puberty. Decades of research have shown that meiotic entry, and germ cell sex determination, are not initiated intrinsically within the germ cells. Instead, meiosis is induced by signals produced by the surrounding somatic cells. More recently, retinoic acid (RA), the active derivative of vitamin A, has been implicated in meiotic induction during fetal XX and postnatal XY germ cell development. Evidence for an intricate system of RA synthesis and degradation in the fetal ovary and testis has emerged, explaining past observations of infertility in vitamin A-deficient rodents. Here we review how meiosis is triggered in fetal ovarian germ cells, paying special attention to the role of RA in this process.
Keyword Germ cell
Retinoic acid
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
Institute for Molecular Bioscience - Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 11 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 10 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Fri, 24 May 2013, 00:50:50 EST by Susan Allen on behalf of Institute for Molecular Bioscience