Molecular phylogeny and evolution of the proteins encoded by coleoid (cuttlefish, octopus, and squid) posterior venom glands

Ruder, Tim, Sunagar, Kartik, Undheim, Eivind A. B., Ali, Syed A., Wai, Tak-Cheung, Low, Dolyce H. W., Jackson, Timothy N. W., King, Glenn F., Antunes, Agostinho and Fry, Bryan G. (2013) Molecular phylogeny and evolution of the proteins encoded by coleoid (cuttlefish, octopus, and squid) posterior venom glands. Journal of Molecular Evolution, 76 4: 192-204. doi:10.1007/s00239-013-9552-5


Author Ruder, Tim
Sunagar, Kartik
Undheim, Eivind A. B.
Ali, Syed A.
Wai, Tak-Cheung
Low, Dolyce H. W.
Jackson, Timothy N. W.
King, Glenn F.
Antunes, Agostinho
Fry, Bryan G.
Title Molecular phylogeny and evolution of the proteins encoded by coleoid (cuttlefish, octopus, and squid) posterior venom glands
Journal name Journal of Molecular Evolution   Check publisher's open access policy
ISSN 0022-2844
1432-1432
Publication date 2013-04-01
Year available 2013
Sub-type Article (original research)
DOI 10.1007/s00239-013-9552-5
Open Access Status Not Open Access
Volume 76
Issue 4
Start page 192
End page 204
Total pages 13
Place of publication New York, United States
Publisher Springer
Language eng
Subject 1105 Ecology, Evolution, Behavior and Systematics
1312 Molecular Biology
1311 Genetics
Abstract In this study, we report for the first time a detailed evaluation of the phylogenetic history and molecular evolution of the major coleoid toxins: CAP, carboxypeptidase, chitinase, metalloprotease GON-domain, hyaluronidase, pacifastin, PLA2, SE-cephalotoxin and serine proteases, with the carboxypeptidase and GON-domain documented for the first time in the coleoid venom arsenal.We show that although a majority of sites in these coleoid venom-encoding genes have evolved under the regime of negative selection, a very small proportion of sites are influenced by the transient selection pressures. Moreover, nearly 70 % of these episodically adapted sites are confined to the molecular surface, highlighting the importance of variation of the toxin surface chemistry. Coleoid venoms were revealed to be as complex as other venoms that have traditionally been the recipient of the bulk of research efforts. The presence of multiple peptide/ protein types in coleoids similar to those present in other animal venoms identifies a convergent strategy, revealing new information as to what characteristics make a peptide/ protein type amenable for recruitment into chemical arsenals. Coleoid venoms have significant potential not only for understanding fundamental aspects of venom evolution but also as an untapped source of novel toxins for use in drug design and discovery.
Keyword Molecular evolution
Coleoid
Cephalopod
Octopus
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID SFRH/BD/61959/2009
PTDC/AACAMB/, 121301/2010 (FCOMP-01-0124-FEDER-019490)
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Biological Sciences Publications
Institute for Molecular Bioscience - Publications
 
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