Recent advance in silica-based engineered nanoparticles for gene therapy

Niu, Yuting, Popat, Amirali, Yu, Meihua, Karmakar, Surajit, Gu, Wenyi and Yu, Chengzhong (2012) Recent advance in silica-based engineered nanoparticles for gene therapy. Therapeutic Delivery, 3 10: 1217-1237. doi:10.4155/tde.12.98


Author Niu, Yuting
Popat, Amirali
Yu, Meihua
Karmakar, Surajit
Gu, Wenyi
Yu, Chengzhong
Title Recent advance in silica-based engineered nanoparticles for gene therapy
Journal name Therapeutic Delivery   Check publisher's open access policy
ISSN 2041-5990
2041-6008
Publication date 2012-10-18
Sub-type Critical review of research, literature review, critical commentary
DOI 10.4155/tde.12.98
Volume 3
Issue 10
Start page 1217
End page 1237
Total pages 11
Place of publication London, United Kingdom
Publisher Future Science
Language eng
Formatted abstract
Gene therapy has attracted much attention in modern society and provides a promising approach for treating genetic disorders, diseases and cancers. Safe and effective vectors are vital tools to deliver genetic molecules to cells. This review summarizes recent advances in the rational design of silica-based nanoparticles and their applications in gene therapy. An overview of different types of genetic agents available for gene therapy is provided. The engineering of various silica nanoparticles is described, which can be used as versatile complexation tools for genetic agents and advanced gene therapy. Several challenges are raised and future research directions in the area of gene
therapy using silica-based nanoparticles are proposed.
Keyword Gene therapy
Genetic agents
Silica nanoparticle
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2013 Collection
Australian Institute for Bioengineering and Nanotechnology Publications
 
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Created: Wed, 17 Apr 2013, 18:48:24 EST by Mr Amirali Popat on behalf of Aust Institute for Bioengineering & Nanotechnology