Vitamin D status and skin cancer risk independent of time outdoors: 11-year prospective study in an Australian community

van der Pols, Jolieke C., Russell, Anne, Bauer, Ulrike, Neale, Rachel E., Kimlin, Michael G. and Green, Adele C. (2013) Vitamin D status and skin cancer risk independent of time outdoors: 11-year prospective study in an Australian community. Journal of Investigative Dermatology, 133 3: 637-641. doi:10.1038/jid.2012.346

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Author van der Pols, Jolieke C.
Russell, Anne
Bauer, Ulrike
Neale, Rachel E.
Kimlin, Michael G.
Green, Adele C.
Title Vitamin D status and skin cancer risk independent of time outdoors: 11-year prospective study in an Australian community
Journal name Journal of Investigative Dermatology   Check publisher's open access policy
ISSN 0022-202X
1523-1747
Publication date 2013-03-01
Year available 2012
Sub-type Article (original research)
DOI 10.1038/jid.2012.346
Open Access Status DOI
Volume 133
Issue 3
Start page 637
End page 641
Total pages 5
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Formatted abstract
Vitamin D may have anti–skin cancer effects, but population-based evidence is lacking. We therefore assessed associations between vitamin D status and skin cancer risk in an Australian subtropical community. We analyzed prospective skin cancer incidence for 11 years following baseline assessment of serum 25(OH)-vitamin D in 1,191 adults (average age 54 years) and used multivariable logistic regression analysis to adjust risk estimates for age, sex, detailed assessments of usual time spent outdoors, phenotypic characteristics, and other possible confounders. Participants with serum 25(OH)-vitamin D concentrations above 75 nmol l−1 versus those below 75 nmol l−1 more often developed basal cell carcinoma (odds ratio (OR)=1.51 (95% confidence interval (CI): 1.10–2.07, P=0.01) and melanoma (OR=2.71 (95% CI: 0.98–7.48, P=0.05)). Squamous cell carcinoma incidence tended to be lower in persons with serum 25(OH)-vitamin D concentrations above 75 nmol l−1 compared with those below 75 nmol l−1 (OR=0.67 (95% CI: 0.44–1.03, P=0.07)). Vitamin D status was not associated with skin cancer incidence when participants were classified as above or below 50 nmol l−1 25(OH)-vitamin D. Our findings do not indicate that the carcinogenicity of high sun exposure can be counteracted by high vitamin D status. High sun exposure is to be avoided as a means to achieve high vitamin D status.
Keyword Randomized controlled trial
Regular sunscreen use
Basal-cell carcinoma
Nonmelanoma
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online 18 October 2012

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Public Health Publications
 
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