Contribution of NOD2 to lung inflammation during Staphylococcus aureus-induced pneumonia

Kapetanovic, Ronan, Jouvion, Gregory, Fitting, Catherine, Parlato, Marianna, Blanchet, Charlene, Huerre, Michel, Cavaillon, Jean-Marc and Adib-Conquy, Minou (2010) Contribution of NOD2 to lung inflammation during Staphylococcus aureus-induced pneumonia. Microbes and Infection, 12 10: 759-767. doi:10.1016/j.micinf.2010.05.003


Author Kapetanovic, Ronan
Jouvion, Gregory
Fitting, Catherine
Parlato, Marianna
Blanchet, Charlene
Huerre, Michel
Cavaillon, Jean-Marc
Adib-Conquy, Minou
Title Contribution of NOD2 to lung inflammation during Staphylococcus aureus-induced pneumonia
Formatted title
Contribution of NOD2 to lung inflammation during Staphylococcus aureus-induced pneumonia
Journal name Microbes and Infection   Check publisher's open access policy
ISSN 1286-4579
1769-714X
Publication date 2010-09-01
Sub-type Article (original research)
DOI 10.1016/j.micinf.2010.05.003
Volume 12
Issue 10
Start page 759
End page 767
Total pages 9
Place of publication Issy les Moulineaux, France
Publisher Elsevier
Language eng
Formatted abstract
Staphylococcus aureus is the most commonly found Gram-positive bacterium in patients admitted in intensive-care units, causing septicaemia or pneumonia. In this work, we investigated the role of NOD2 in S. aureus-induced pneumonia. We found that the absence of NOD2 affected weight loss and recovery speed. Nod2−/− mice showed a reduced lung inflammation in comparison to wild-type animals, with lower presence of cytokines in broncho-alveolar lavage fluids and reduced recruitment of neutrophils. Furthermore, histological analysis of the lungs revealed less severe lesions in Nod2−/− mice at day 2 and day 7 post-infection. In conclusion, we demonstrated that NOD2 is not a crucial receptor to fight S. aureus-induced pneumonia, but that it contributes to the inflammatory response in the lungs. Interestingly, the absence of NOD2 led to a lesser inflammation and was finally beneficial for the animal recovery.
Keyword Innate immunity
Cytokines
Inflammation
Staphylococcus aureus
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
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Created: Wed, 17 Apr 2013, 00:20:59 EST by Susan Allen on behalf of Institute for Molecular Bioscience