Cerebral assymmetry: a quantitative, multifactorial, and plastic brain phenotype

Renteria, Miguel E. (2012) Cerebral assymmetry: a quantitative, multifactorial, and plastic brain phenotype. Twin Research and Human Genetics, 15 3: 401-413. doi:10.1017/thg.2012.13

Author Renteria, Miguel E.
Title Cerebral assymmetry: a quantitative, multifactorial, and plastic brain phenotype
Journal name Twin Research and Human Genetics   Check publisher's open access policy
ISSN 1832-4274
Publication date 2012-06-01
Sub-type Article (original research)
DOI 10.1017/thg.2012.13
Open Access Status
Volume 15
Issue 3
Start page 401
End page 413
Total pages 13
Place of publication Cambridge, United Kingdom
Publisher Cambridge University Press
Language eng
Abstract The longitudinal fissure separates the human brain into two hemispheres that remain connected through the corpus callosum. The left and the right halves of the brain resemble each other, and almost every structure present in one side has an equivalent structure in the other. Despite this exceptional correspondence, the two hemispheres also display important anatomical differences and there is marked lateralization of certain cognitive and motor functions such as language and handedness. However, the mechanisms that underlie the establishment of these hemispheric specializations, as well as their physiological and behavioral implications, remain largely unknown. Thanks to recent advances in neuroimaging, a series of studies documenting variation in symmetry and asymmetry as a function of age, gender, brain region, and pathological state, have been published in the past decade. Here, we review evidence of normal and atypical cerebral asymmetry, and the factors that influence it at the macrostructural level. Given the prominent role that cerebral asymmetry plays in the organization of the brain, and its possible implication in neurodevelopmental and psychiatric conditions, further research in this area is anticipated.
Keyword Magnetic resonance imaging
Cerebral asymmetry
Brain lateralization
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Special Issue 03 (Genetics of brain structure and function)

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Psychology Publications
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