Comparison of Left Ventricular Dyssynchrony by Two-Dimensional Speckle Tracking Versus Tissue Doppler Imaging in Patients With Non-ST-Elevation Myocardial Infarction and Preserved Left Ventricular Systolic Function

Ng, Arnold C. T., Tran, Da T., Newman, Mark, Allman, Christine, Vidaic, Jane and Leung, Dominic Y. (2008) Comparison of Left Ventricular Dyssynchrony by Two-Dimensional Speckle Tracking Versus Tissue Doppler Imaging in Patients With Non-ST-Elevation Myocardial Infarction and Preserved Left Ventricular Systolic Function. American Journal of Cardiology, 102 9: 1146-1150. doi:10.1016/j.amjcard.2008.06.033


Author Ng, Arnold C. T.
Tran, Da T.
Newman, Mark
Allman, Christine
Vidaic, Jane
Leung, Dominic Y.
Title Comparison of Left Ventricular Dyssynchrony by Two-Dimensional Speckle Tracking Versus Tissue Doppler Imaging in Patients With Non-ST-Elevation Myocardial Infarction and Preserved Left Ventricular Systolic Function
Journal name American Journal of Cardiology   Check publisher's open access policy
ISSN 0002-9149
1879-1913
Publication date 2008-11-01
Year available 2008
Sub-type Article (original research)
DOI 10.1016/j.amjcard.2008.06.033
Volume 102
Issue 9
Start page 1146
End page 1150
Total pages 5
Place of publication Bridgewater, NJ United States
Publisher Excerpta Medica
Language eng
Formatted abstract
Assessment of left ventricular (LV) dyssynchrony after myocardial infarction has prognostic value. There were no reference ranges for 2-dimensional (2D) speckle tracking synchrony, and it was unclear whether color tissue Doppler imaging and 2D speckle tracking synchrony indexes were comparable. One hundred twenty-two healthy volunteers and 40 patients with non-ST-elevation myocardial infarction (NSTEMI) had LV systolic and diastolic synchrony, defined as the SD of time to peak systolic (2D-SDTs) and early diastolic (2D-SDTe) velocities in the 12 basal and mid segments using 2D speckle tracking, respectively. Mean 2D-SDTs and 2D-SDTe were 29.4 ± 16.1 and 14.2 ± 6.1 ms in healthy subjects, respectively. Gender and mean 2D systolic velocity independently predicted 2D-SDTs, and mean 2D early diastolic velocity independently predicted 2D-SDTe. Bland-Altman analysis showed suboptimal agreement between 2D speckle tracking and tissue Doppler imaging dyssynchrony indexes. 2D speckle tracking showed lower coefficients of variation for time to peak systolic and early diastolic velocities than tissue Doppler imaging. There were no significant differences in coefficients of variation for 2D speckle tracking systolic and diastolic synchrony for high versus low frame rates. Patients with NSTEMI had significantly lower ejection fraction, but higher LV mass and wall stress than healthy subjects. Only 2D-SDTs was significantly higher in patients with NSTEMI compared with healthy subjects (37.1 ± 22.5 vs 29.4 ± 16.1 ms; p = 0.02). In conclusion, 2D-SDTs was gender specific and influenced by global systolic function, and 2D-SDTe was influenced by global diastolic function. 2D speckle tracking and tissue Doppler imaging dyssynchrony indexes were not comparable. 2D speckle tracking may be a more sensitive discriminator of LV systolic dyssynchrony than tissue Doppler imaging.
Keyword Cardiac Resynchronization Therapy
Heart failure
Diastolic Asynchrony
Echocardiography
Synchronicity
Validation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Mon, 15 Apr 2013, 10:09:37 EST by Dr Chin Tse Arnold Ng on behalf of School of Medicine